Evidence map›Paper›PMID 41270231›Full record

ArticleChemistry & biodiversity2026

Anti-Aging Activity of Rosa roxburghii Nano-Emulsion in Caenorhabditis elegans: Preparation, Characterization, and Evaluation.

Xiaowei Zhou, Xiaojuan Li, Gaigai Xu, Bing Bai, Zixiu Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaowei ZhouCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Xiaojuan LiCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Gaigai XuCollege of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Bing BaiCollege of Tobacco Science and Engineering, Zhengzhou University of Light Industry, Zhengzhou, China.
Zixiu WangCollege of Pharmacy, Gannan Medical University, Ganzhou, China.ORCID https://orcid.org/0000-0002-2642-5037

Funding

Henan Provincial Science and Technology Research Project 242102310474
6 · The paper itself

Abstract

The triterpenoids in Rosa roxburghii fruit (RRF) show various pharmacological activities such as antioxidant, anti-ageing, and anti-atherosclerotic. However, the therapeutic potential of these triterpenoids is limited by poor aqueous solubility, low bioavailability, and rapid systemic clearance, which can hinder their oral effectiveness. The objective of this study was to prepare an RRF nano-emulsion (RRFNE), which is conducive to enhancing the bioactivity of RRF following oral administration. The polydispersity index of RRFNE was 0.18, diameter 43.95 nm, zeta potential 36.37 mV, and triterpenoids loading 25.02 mg/g. Compared to RRF-100, the longest lifespan of RRFNE-100 was extended by 8.58%. The activities of catalase, superoxide dismutase (SOD), and glutathione peroxidase in RRFNE-100 increased by 11.33%, 16.19%, and 5.37% (p < 0.01), respectively, and malondialdehyde levels decreased by 8.98%. Additionally, RRFNE enhances the antioxidant capacity of C. elegans by activating the expression of SIR-2.1, DAF-16, and SOD-3, thus extending the nematodes' lifespan without affecting their reproductive ability.

Indexed as

AgingAntioxidantsCaenorhabditis elegansNanoparticlesPlant ExtractsRosaTriterpenesAnimalsEmulsionsParticle SizeSuperoxide DismutaseAntioxidantsEmulsionsPlant ExtractsSuperoxide DismutaseTriterpenesanti‐agingCaenorhabditis elegansnano‐emulsionRosa roxburghii

Identifiers

PMID41270231
PMCPMC13421854

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.