Evidence map›Paper›PMID 41270295›Full record

ReviewAnnual review of biophysics2026

The Evolution of Lipids from Solvents to Substrates.

Aninda Dutta, Charlotte Hannis, Nathan Feinberg, Linda Columbus

Abstract readReview
In one paragraph

Review in Annual review of biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aninda DuttaDepartment of Chemistry, University of Virginia, Charlottesville, Virginia, USA; email: hyq8ne@virginia.edu, lc4zs@virginia.edu.
Charlotte HannisDepartment of Chemistry, University of Virginia, Charlottesville, Virginia, USA; email: hyq8ne@virginia.edu, lc4zs@virginia.edu.
Nathan FeinbergDepartment of Chemistry, University of Virginia, Charlottesville, Virginia, USA; email: hyq8ne@virginia.edu, lc4zs@virginia.edu.
Linda ColumbusDepartment of Chemistry, University of Virginia, Charlottesville, Virginia, USA; email: hyq8ne@virginia.edu, lc4zs@virginia.edu.

Funding

Biophysical understanding of pathogen-host membrane protein interactions for drug discovery and deliveryR35GM131829 · NIGMS · UNIVERSITY OF VIRGINIA · PI Linda M Columbus · 2019 to 2026
$3.2M
NIGMS NIH HHS R35 GM131829
6 · The paper itself

Abstract

While the role of water in soluble protein structure and function is well-established, the analogous role of lipids as a solvent for membrane proteins is less understood. Bacterial membranes exhibit extraordinary lipid diversity, with

Indexed as

Evolution, MolecularLipidsSolventsMembrane ProteinsThermodynamicsLipidsMembrane ProteinsSolventslipid cofactorslipidspreferential solventsubstrateswaterα-IMPs

Identifiers

PMID41270295
PMCPMC12951313

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.