ArticleBMJ open2025
Association between maternal and neonatal biochemical variables at delivery in pregnancies complicated by hypertensive disorders: a retrospective chart review in a tertiary referral unit.
Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
objectiveTo examine the association between maternal and neonatal biochemical variables in babies born to mothers with hypertensive disorders of pregnancy (HDP) and admitted to the neonatal unit within 24 hours of delivery.
designRetrospective chart review study.
settingSpecialised antenatal hypertension clinic and neonatal unit in a tertiary unit referral hospital. PATIENTS: Pregnancies complicated with HDP (N=282) and their neonates if admitted to the neonatal unit within 24 hours of delivery.
interventionsWe examined the association between maternal and neonatal biochemical variables, after controlling for maternal, neonatal and pregnancy characteristics.
resultsThere were strong associations and independent prediction of neonatal levels by maternal levels for urea, creatinine, sodium and calcium. The highest associations were between neonatal and maternal urea and creatinine, where the only predictor was the respective maternal variable (model R
conclusionsMaternal levels of urea, creatinine, sodium and calcium, in a pregnancy complicated by HDP, should be taken into consideration by both the obstetric and neonatal teams when deciding on timing of delivery and providing intensive monitoring.
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