ArticleNature communications2025
Voltage-gated ion channel diversity underlies neuronal excitability and nervous system evolution.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Mitochondrial oxidative stress and ion-channel suppression reveal a distinct neurotoxic profile of fentanyl analogues in a human neuronal model.Archives of toxicology · 2026Article
- Deep mutational scan of the pore of the cold-sensing TRPM8 channel.bioRxiv : the preprint server for biology · 2026Article
- The grand challenge in cellular neurophysiology.Frontiers in cellular neuroscience · 2026Article
- Toward precision medicine inFrontiers in neurologyArticle
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nervous systems function via electrical excitability mediated by ion channels, an ancient preneuronal feature that many cells use to rapidly adjust behavior. Here, we systematically study the evolutionary paths to neuronal excitability by characterizing the voltage-gated ion channel complements (VGL-chanomes) of 623 organisms, dissecting their expression in 11 whole-body cell atlases and 3 entire nervous systems, and recording electrical properties of cnidarian neurons in Nematostella. We find a disconnect between ion channel availability and nervous system complexity and instead find an association with lifestyle and behavior. Cell-type restricted VGL-chanome expression predated the emergence of nervous systems, and multiple gene-family expansions and contractions have led to a surprising pattern: it is not the number of ion channels, but rather their diversity and restrictive recruitment that is a hallmark of neuronal complexity. These findings suggest that the evolution of complex nervous systems was not a stepwise progression of expanding complexity but a convergent path to diversity.
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Registered trials
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