Evidence map›Paper›PMID 41271841›Full record

ArticleScientific reports2025

Feasibility of ultrasound-mediated blood-brain barrier opening in sheep using sonolucent cranial implants.

Jae Song, Gina Richter-Stretton, Matthew Pelekanos, Corbin Clawson, Siamak Saifzadeh, Craig Simon, Gerhard Leinenga, Rachel de Las Heras, Hamish Alexander, Jürgen Götz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jae SongClem Jones Centre for Ageing Dementia Research (CJCADR), Queensland Brain Institute (QBI), The University of Queensland, Brisbane, QLD, 4072, Australia.
Gina Richter-StrettonClem Jones Centre for Ageing Dementia Research (CJCADR), Queensland Brain Institute (QBI), The University of Queensland, Brisbane, QLD, 4072, Australia.
Matthew PelekanosClem Jones Centre for Ageing Dementia Research (CJCADR), Queensland Brain Institute (QBI), The University of Queensland, Brisbane, QLD, 4072, Australia.
Corbin ClawsonLongeviti Neuro Solutions, 101 W. Dickman St., Suite 500, Baltimore, MD, 21230, USA.
Siamak SaifzadehMedical Engineering Research Facility (MERF), Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, Prince Charles Hospital Campus, Brisbane, QLD, 4032, Australia.
Craig SimonMedical Engineering Research Facility (MERF), Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology, Prince Charles Hospital Campus, Brisbane, QLD, 4032, Australia.
Gerhard LeinengaClem Jones Centre for Ageing Dementia Research (CJCADR), Queensland Brain Institute (QBI), The University of Queensland, Brisbane, QLD, 4072, Australia.
Rachel de Las HerasClem Jones Centre for Ageing Dementia Research (CJCADR), Queensland Brain Institute (QBI), The University of Queensland, Brisbane, QLD, 4072, Australia.
Hamish AlexanderKenneth G Jamieson Neurosurgery Department, Faculty of Medicine, Royal Brisbane and Women's Hospital, The University of Queensland Herston, Brisbane, QLD, 4006, Australia. Hamish.Alexander@health.qld.gov.au.ORCID http://orcid.org/0000-0001-5528-8214
Jürgen GötzClem Jones Centre for Ageing Dementia Research (CJCADR), Queensland Brain Institute (QBI), The University of Queensland, Brisbane, QLD, 4072, Australia. j.goetz@uq.edu.au.ORCID http://orcid.org/0000-0001-8501-7896

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug delivery to the brain presents a major hurdle in developing treatments for neurological disorders. A noninvasive strategy addressing this is transcranial focused ultrasound with microbubbles (FUS

Indexed as

Blood-Brain BarrierDrug Delivery SystemsSkullAnimalsFeasibility StudiesMicrobubblesProstheses and ImplantsSheepAttenuationCranioplastyFocused ultrasound (FUS)Low-intensity ultrasoundPassive cavitation detectorPoly(methyl methacrylate) (PMMA)

Identifiers

PMID41271841
PMCPMC12638990

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.