ArticleScientific reports2025
Relationship between coffee concentration and bowel motility using bowel-sound-based stimulus-response plots in healthy individuals.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Coffee is consumed worldwide and exerts multifaceted physiological effects, yet evidence on its short-term impact on intestinal motility remains inconsistent. We investigated 40-min changes in motility after coffee prepared at three concentrations (weak, strong, extra strong) in 10 healthy young men using bowel-sound–based stimulus–response plots (BSSRPs) derived from BS segments per minute. Concentrations were created by precisely adjusting instant-coffee powder per 150 mL serving at 45 °C to control total dissolved solids. Motility increased versus baseline in both post-ingestion phases (Gastric 0–10 min; Intestinal 20–40 min). Planned pairwise comparisons did not detect differences among concentrations within phase, whereas exploratory BSSRPs suggested a concentration-ordered inverse pattern (WC ≥ SC ≥ Ex.SC) that persisted across 0–40 min. These findings indicate that coffee acutely modulates intestinal motility under fixed temperature/volume conditions, while any concentration dependence remains provisional. This work provides a basis for more systematic evaluation of coffee’s physiological effects; future studies should standardize composition, temperature, and volume, include a matched hot-water control, and be powered to test concentration effects and mechanisms directly.
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