ArticleScientific reports2025
Inhibition of FKBP5 alleviates obstetric antiphospholipid syndrome by regulating macrophage polarization.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- FKBP5 isoforms shape immune pathways related to tumor tolerance.Cell death discovery · 2026Article
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Abstract
Immune homeostasis disturbance within the placental microenvironment plays a key role in the pathogenesis of obstetric antiphospholipid syndrome (OAPS), although the underlying mechanisms remain poorly understood. This study aimed to investigate the immune regulatory role of FK506-binding protein 5 (FKBP5) in OAPS-associated pathological pregnancies. RNA sequencing and immunocytotyping were performed on decidual tissues from OAPS patients and healthy controls. Bone marrow-derived macrophages (BMDMs) polarization assays and macrophage‒trophoblast coculture models were employed to explore the effects and mechanisms of FKBP5 on macrophage polarization at the maternal-fetal interface. We applied an animal model of OAPS and comprehensively evaluated the therapeutic effects of the FKBP5 inhibitor SAFit2 on OAPS. The results revealed significantly greater expression of FKBP5 and inflammation-related factors in OAPS patients than in healthy controls. An imbalance in macrophage polarization was observed, with an increase in M1 (iNOS
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