Evidence map›Paper›PMID 41271981›Full record

ArticleScientific reports2025

Lung tissue T cells are activated in chronic obstructive pulmonary disease with non-small cell lung cancer patients.

Mari Tone, Tomomi Isono, Yoko Yamamoto, Yoshito Takeda, Yasushi Shintani, Atsushi Kumanogoh, Hisashi Wada, Kota Iwahori

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mari ToneDepartment of Cancer Immunotherapy, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Tomomi IsonoDepartment of General Thoracic Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Yoko YamamotoDepartment of General Thoracic Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Yoshito TakedaDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Yasushi ShintaniDepartment of General Thoracic Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Atsushi KumanogohDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Hisashi WadaDepartment of Clinical Research in Tumor Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Kota IwahoriDepartment of Cancer Immunotherapy, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan. iwahori@climm.med.osaka-u.ac.jp.

Funding

Japan Agency for Medical Research and Development 24ama221340h9901Japan Society for the Promotion of Science 24K11315
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the respiratory tract and is associated with an increased risk of lung cancer. Non-small cell lung cancer (NSCLC) patients with COPD have been shown to exhibit favorable responses to anti-PD-1/PD-L1 therapy. In the present study, we investigated T cell profiles and functions in the lung tissues of NSCLC patients with or without COPD to provide the rationale for immunotherapy of NSCLC patients with COPD. Abundant PD-1

Indexed as

Carcinoma, Non-Small-Cell LungLungLung NeoplasmsLymphocyte ActivationPulmonary Disease, Chronic ObstructiveT-LymphocytesAgedAntigens, CDFemaleHepatitis A Virus Cellular Receptor 2HumansIntegrin alpha ChainsInterferon-gammaMaleMemory T CellsMiddle Agedalpha E integrinsAntigens, CDHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2Integrin alpha ChainsInterferon-gammaPDCD1 protein, humanProgrammed Cell Death 1 ReceptorChronic obstructive pulmonary diseaseImmunotherapyLung cancerT cells

Identifiers

PMID41271981
PMCPMC12638936

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.