Evidence map›Paper›PMID 41272152›Full record

ArticleScientific reports2025

Altered systemic bioenergetic reserve in chronic kidney disease predisposes hearts to worse functional outcomes.

Megan Young, Malene Aastrup, Nikayla Patel, Fenn Cullen, Esben S S Hansen, James E Clark, Thomas R Eykyn, Michael Væggemose, Ana Vujic, Loucia Karatzia and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Megan YoungBarts and the London Faculty of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Malene AastrupThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Nikayla PatelBarts and the London Faculty of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Fenn CullenBarts and the London Faculty of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Esben S S HansenThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
James E ClarkThe Rayne Institute, School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Thomas R EykynKing's College London BHF Centre of Research Excellence, London, UK.
Michael VæggemoseThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Ana VujicDepartment of Medicine, University of Cambridge, Cambridge, UK.
Loucia KaratziaBarts and the London Faculty of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Ladislav ValkovičOxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, Oxford, UK.
Jack J J J MillerThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Niels H BuusDepartment of Renal Medicine, Aarhus University, Aarhus, Denmark.
Christoffer LaustsenThe MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Magdi M YaqoobBarts and the London Faculty of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Dunja AksentijevicBarts and the London Faculty of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK. d.aksentijevic@qmul.ac.uk.

Funding

APVV 21-0299Barts Charity G-002145British Heart Foundation FS/4YPhD/P/20/34016British Heart Foundation RE/24/130035EPSRC WT/203148/Z/16/ZNovo Nordisk Fonden NNF21OC0068683VEGA 2/0004/23Wellcome TrustWellcome Trust 221604/Z/20/Z
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is characterised by progressive loss of kidney function and structural damage, which contributes to systemic complications, including cardiovascular dysfunction. Inter-organ metabolic interactions are increasingly recognised as important in the pathophysiology of CKD, but the extent to which systemic bioenergetic deficits contribute to cardiac dysfunction remains unclear. We investigated cardiac and systemic metabolic remodeling in two rat models of CKD with distinct aetiologies: glomerulosclerosis induced by partial nephrectomy and interstitial fibrosis induced by an adenine-rich diet. Despite differing renal pathology, both models exhibited comparable cardiac dysfunction, including impaired recovery following 25 min of ischaemia.

Indexed as

Energy MetabolismHeartMyocardiumRenal Insufficiency, ChronicAnimalsDisease Models, AnimalHumansKidneyLiverMagnetic Resonance SpectroscopyMaleMetabolomicsMuscle, SkeletalRats

Identifiers

PMID41272152
PMCPMC12638317

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.