Evidence map›Paper›PMID 41272167›Full record

ArticleNature immunology2025

Pseudokinase STK40 limits T cell exhaustion through COP1-dependent degradation of AP1-family transcription factors.

Svetlana Altshuler-Keylin, Nicole Caduff, Isabel E Ishizuka, Rohit Reja, Katherine Nutsch, Chan Gao, Joy Wang, Ulrike Kaufmann, Mayra Cruz Tleugabulova, Elizabeth Dixon and 11 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. STK40 inhibits profibrotic Arg1Acta pharmacologica Sinica · 2026
    Article
  2. Post-translational modifications in CD8Frontiers in immunology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Svetlana Altshuler-Keylin *Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Nicole Caduff *Department of Research Oncology, Genentech, South San Francisco, CA, USA.
Isabel E IshizukaDepartment of Research Oncology, Genentech, South San Francisco, CA, USA.
Rohit RejaDepartment of Computational Sciences, Genentech, South San Francisco, CA, USA.
Katherine NutschDepartment of Research Oncology, Genentech, South San Francisco, CA, USA.
Chan GaoDepartment of Translational Oncology, Genentech, South San Francisco, CA, USA.
Joy WangDepartment of Translational Oncology, Genentech, South San Francisco, CA, USA.
Ulrike KaufmannDepartment of Translational Oncology, Genentech, South San Francisco, CA, USA.
Mayra Cruz TleugabulovaDepartment of Research Oncology, Genentech, South San Francisco, CA, USA.
Elizabeth DixonDepartment of Research Oncology, Genentech, South San Francisco, CA, USA.
Hannah Little-HooyDepartment of Translational Immunology, Genentech, South San Francisco, CA, USA.
Rachana PradhanDepartment of Computational Sciences, Genentech, South San Francisco, CA, USA.
Rosa Barreira da SilvaDepartment of Immunology, Genentech, South San Francisco, CA, USA.
Teresita L ArenzanaDepartment of Research Oncology, Genentech, South San Francisco, CA, USA.
Min XuDepartment of Translational Immunology, Genentech, South San Francisco, CA, USA.
Mark S WilsonDepartment of Immunology, Genentech, South San Francisco, CA, USA.
Jill SchartnerDepartment of Translational Oncology, Genentech, South San Francisco, CA, USA.
Soyoung A OhDepartment of Research Oncology, Genentech, South San Francisco, CA, USA.
Kim NewtonDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4197-0340
Vishva M DixitDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA. dixit@gene.com.ORCID http://orcid.org/0000-0001-6983-0326
Sascha RutzDepartment of Research Oncology, Genentech, South San Francisco, CA, USA. sascha.rutz@gilead.com.ORCID http://orcid.org/0000-0003-2431-0938

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serine/threonine kinase 40 (STK40) belongs to the Tribbles family of pseudokinases, which serve as substrate adaptors for the CRL4

Indexed as

Protein Serine-Threonine KinasesT-LymphocytesTranscription Factor AP-1Ubiquitin-Protein LigasesAnimalsCell ProliferationHumansMiceMice, Inbred C57BLMice, KnockoutNuclear ProteinsProteolysisT-Cell ExhaustionCOP1 protein, mouseNuclear ProteinsProtein Serine-Threonine KinasesTranscription Factor AP-1Ubiquitin-Protein Ligases

Identifiers

PMID41272167

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.