Evidence map›Paper›PMID 41272186›Full record

ArticleScientific reports2025

Design and synthesis of 1,2,3-triazole thiadiazole hybrids with in vitro and in silico evaluation of their anti-inflammatory and anti-alzheimer activities.

Ahmed R Rabee, Hamida Abdel-Hamid, Saied M Soliman, Samah Ashraf, Ahmed A Sobhy, Doaa Ahmad Ghareeb, Aalaa K Saad, Mohamed Hagar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ahmed R RabeeChemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt. ahmedrabee@alexu.edu.eg.
Hamida Abdel-HamidChemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt.
Saied M SolimanChemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt.
Samah AshrafBio-Screening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
Ahmed A SobhyBio-Screening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
Doaa Ahmad GhareebBio-Screening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
Aalaa K SaadChemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt.
Mohamed HagarChemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt. mohamedhaggar@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nano technology possesses a role in the enhancement of anti-inflammatory and anti-Alzheimer activities of the synthesized triazole/thiadiazole hybrids 3a-c. Selective propargylation of 5-amino-1,3,4-thiadiazole-2-thiol with propargyl bromide and triethyl amine followed by Click reaction with different azides to afford 1,2,3-triazole/thiadiazole hybrids 3a-c. The structure of the synthesized compounds was confirmed using different spectroscopic analysis such as FT-IR,

Indexed as

Alzheimer DiseaseAnti-Inflammatory AgentsThiadiazolesTriazolesAcetylcholinesteraseCholinesterase InhibitorsDrug DesignHumansMolecular Docking SimulationNanoparticlesAcetylcholinesteraseAnti-Inflammatory AgentsCholinesterase InhibitorsThiadiazolesTriazoles1,2,3-triazoleChitosan nanoparticlesDFT studiesMolecular dockingThiadiazole

Identifiers

PMID41272186
PMCPMC12638865

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.