Evidence map›Paper›PMID 41272243›Full record

Observational studyScientific reports2025

Electrophysiological resting-state signatures link polygenic scores to general intelligence.

Rebecca Engler, Christina Stammen, Stefan Arnau, Javier Schneider Penate, Dorothea Metzen, Jan Digutsch, Patrick D Gajewski, Stephan Getzmann, Christoph Fraenz, Jörg Reinders and 11 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05155397 (The Dortmund Vital Study), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05155397 active not recruitingnot on this map

The Dortmund Vital Study: Impact of Biological and Lifestyle Factors on Cognitive Performace and Work Ability Across the Lifespan. An Interdisciplinary, Cross-sectional and Longitudinal Study

TypeobservationalSponsorTechnical University of DortmundRan2016 to 2037Enrolled627ConditionsAge-related Cognitive Decline
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Rebecca EnglerDepartment of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.
Christina StammenDepartment of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.
Stefan ArnauDepartment of Ergonomics, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.
Javier Schneider PenateDepartment of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, 44801, Bochum, Germany.
Dorothea MetzenInstitute of Psychology, Department of Educational Sciences and Psychology, TU Dortmund University, 44227, Dortmund, Germany.
Jan DigutschDepartment of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.
Patrick D GajewskiDepartment of Ergonomics, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.
Stephan GetzmannDepartment of Ergonomics, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.
Christoph FraenzDepartment of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.
Jörg ReindersDepartment of Toxicology, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.
Manuel C VoelkleDepartment of Psychology, Humboldt-Universität zu Berlin, 10117, Berlin, Germany.
Fabian StreitDepartment Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany.
Sebastian OcklenburgDepartment of Psychology, Medical School Hamburg, 20457, Hamburg, Germany.
Daniel SchneiderDepartment of Ergonomics, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.
Michael BurkeDepartment of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.
Jan G HengstlerDepartment of Toxicology, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.
Carsten WatzlDepartment of Immunology, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.
Michael A NitscheDepartment of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.
Robert KumstaGerman Center for Mental Health (DZPG), partner site Bochum/Marburg, Bochum, Germany.
Edmund WascherDepartment of Ergonomics, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.
Erhan GençDepartment of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany. genc@ifado.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intelligence is associated with important life outcomes. Behavioral, genetic, structural, and functional brain correlates of intelligence have been studied for decades, but questions remain as to how genetics are related to trait expression and what intermediary role brain properties play. This study investigated these mediations in a representative sample of 434 individuals, comprising young and older adults. Polygenic scores (PGS) for intelligence were calculated. Resting-state EEG recordings were analyzed using graph theory quantifying functional connectivity across different frequencies. We tested whether global and local graph metrics like efficiency and clustering mediated the association between PGS and intelligence. PGS significantly predicted variance in intelligence and were related to frequency-specific graph metrics in areas predominantly located in parieto-frontal regions, which in turn were associated with intelligence. These findings, based on the first study linking PGS to intelligence using EEG-derived graph metrics, identify candidate pathways through which genetic variation may shape intelligence, providing a foundation for future hypothesis-driven investigations. Data for this study were collected as part of the Dortmund Vital Study ( https://www.researchprotocols.org/2022/3/e32352 ; ClinicalTrials.gov: NCT05155397).

Indexed as

BrainIntelligenceMultifactorial InheritanceAdultAgedElectroencephalographyFemaleHumansMaleMiddle AgedRestYoung AdultEEGFunctional connectivityGraph theoryIntelligencePolygenic scores

Identifiers

PMID41272243
PMCPMC12638761

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.