Evidence map›Paper›PMID 41273056›Full record

ArticleDevelopmental neurobiology2026

Adolescent White Matter Maturation Mediates Epigenetic Associations With Cognitive Development.

Dawn Jensen, Jiayu Chen, Jessica A Turner, Julia M Stephen, Yu-Ping Wang, Tony W Wilson, Vince D Calhoun, Jingyu Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dawn JensenTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology, and Emory University), Atlanta, Georgia, USA.ORCID 0000-0002-5066-322X
Jiayu ChenTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology, and Emory University), Atlanta, Georgia, USA.
Jessica A TurnerDepartment of Psychiatry and Behavioral Health, Ohio State University, Columbus, Ohio, USA.
Julia M StephenThe Mind Research Network, Albuquerque, New Mexico, USA.ORCID 0000-0003-2486-747X
Yu-Ping WangDepartment of Biomedical Engineering, Tulane University, New Orleans, Louisiana, USA.
Tony W WilsonInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, Nebraska, USA.ORCID 0000-0002-5053-8306
Vince D CalhounTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology, and Emory University), Atlanta, Georgia, USA.
Jingyu LiuTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS): (Georgia State University, Georgia Institute of Technology, and Emory University), Atlanta, Georgia, USA.

Funding

Stress-Induced Aberrations in the Mitochondrial Redox Environment Impact Developing Neural Circuits Supporting Cognitive ControlP20GM144641 · NIGMS · FATHER FLANAGAN'S BOYS' HOME · PI Giorgia Picci · 2022 to 2026
$15.1M
DEVELOPMENTAL MULTIMODAL IMAGING OF NEUROCOGNITIVE DYNAMICS (DEV-MIND)R01MH121101 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WILSON, TONY W · 2019 to 2023
$5.8M
National Science Foundation 1539067National Science Foundation 2112455National Science Foundation 2316421NIGMS NIH HHS P20 GM144641NIH HHS P20-GM122734NIH HHS P50-AA22534NIH HHS R01-MH118695NIH HHS R01-MH121101NIH HHS R56-MH124925NIMH NIH HHS R01 MH121101NSF 1539067NSF 2316421
6 · The paper itself

Abstract

One hallmark of brain maturation in adolescence is increased myelination (fractional anisotropy [FA]) of the axons, although the epigenetic drivers of this stage of neurodevelopment are as yet poorly understood. Our previous study of a longitudinal cohort of normally developing adolescents, aged nine to fourteen, established the connections between changes in DNA methylation (DNAm) at seven cytosine-phosphate-guanine (CpG) sites in genes highly expressed in the brain to grey matter maturation as well as cognitive improvement. Continuing that work, we investigate the relationships between the changes in DNAm of these genes (GRIN2D, GABRB3, KCNC1, SLC12A9, CHD5, STXBP5, and NFASC), four networks of FA change, and scores from seven cognitive tests. The demethylation of the CpGs over time was significantly related to a brain network highlighting FA increases in regions associated with maturation of interhemispheric connectivity. Mediation analysis found that this same network mediated the relationship between decreases in DNAm of four of these genes and increases in overall cognitive performance. These relationships suggest that changes in DNAm of genes involved in myelination and the excitatory/inhibitory balance in the brain might be driving maturation of white matter, which in turn is implicated in the improved cognitive performance seen in adolescents.

Indexed as

BrainCognitionEpigenesis, GeneticWhite MatterAdolescentChildDNA MethylationFemaleHumansLongitudinal StudiesMaleadolescent developmentcognitiondiffusion tensor imaging (DTI)methylationneuroimaging epigeneticswhite matter

Identifiers

PMID41273056
PMCPMC12639353

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.