Evidence map›Paper›PMID 41273127›Full record

ArticleMolecular nutrition & food research2025

The Nutrigenomic Effect of Mela Rosa Marchigiana Callus Extract on Cellular Senescence: Insight From a Preliminary In Vitro Study.

Chiara Rucci, Enrica Sordini, Giuseppe Persico, Eugenia Ciurlia, Noemi Pappagallo, Giulia Matacchione, Marco Giorgio, Daniele Fraternale, Maria Cristina Albertini, Dale Annear and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Chiara RucciSchool of Advanced Studies, University of Camerino, Camerino, MC, Italy.ORCID 0009-0009-4403-2702
Enrica SordiniMolecular Pathology Laboratory "PaoLa", Department of Biomolecular Sciences, University of Urbino Carlo Bo, Fano, PU, Italy.
Giuseppe PersicoDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Eugenia CiurliaMolecular Pathology Laboratory "PaoLa", Department of Biomolecular Sciences, University of Urbino Carlo Bo, Fano, PU, Italy.
Noemi PappagalloDepartment of Biomolecular Sciences, DISB, University of Urbino Carlo Bo, Urbino, PU, Italy.
Giulia MatacchioneCenter of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy.
Marco GiorgioDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Daniele FraternaleDepartment of Biomolecular Sciences, DISB, University of Urbino Carlo Bo, Urbino, PU, Italy.
Maria Cristina AlbertiniDepartment of Biomolecular Sciences, DISB, University of Urbino Carlo Bo, Urbino, PU, Italy.
Dale AnnearCenter of Medical Genetics, University of Antwerp, Antwerp, Belgium.
Peter De RijkNeuromics Support Facility, VIB Center for Molecular Neurology, Antwerp, Belgium.
Tim De PooterNeuromics Support Facility, VIB Center for Molecular Neurology, Antwerp, Belgium.
Mojca StrazisarNeuromics Support Facility, VIB Center for Molecular Neurology, Antwerp, Belgium.
Wim Vanden BergheDepartment of Biomedical Sciences, Cell Death Epigenetic Signaling Lab, University of Antwerp, Antwerp, Belgium.
Laura BordoniUnit of Molecular Biology and Nutrigenomics, School of Pharmacy, University of Camerino, Camerino, MC, Italy.
Stefano AmatoriMolecular Pathology Laboratory "PaoLa", Department of Biomolecular Sciences, University of Urbino Carlo Bo, Fano, PU, Italy.
Rosita GabbianelliUnit of Molecular Biology and Nutrigenomics, School of Pharmacy, University of Camerino, Camerino, MC, Italy.ORCID 0000-0003-0037-7740

Funding

Chiara Rucci's scholarship and reagents VITALITY - CUPJ13C22000430001European Union-NextGenerationEU, Mission 4, Component 2, under the Italian Ministry of University and Research (MUR) National Innovation Ecosystem ECS00000041
6 · The paper itself

Abstract

Mela Rosa Marchigiana (MRM) is an apple variety cultured in the center of Italy. Calluses derived from in vitro culture of MRM explants were used to obtain an ethanolic extract rich in pentacyclic triterpenic acids with putative anti-inflammatory and anti-aging effects. In this study, we investigated the transcriptomic and epigenetic effects of MRM callus extract (MRME) in an in vitro model of cellular senescence. Senescent HUVECs (sHUVECs) were treated with MRME. Transcriptomic analysis was performed to compare young HUVECs (yHUVECs) with sHUVECs and to evaluate the MRME's effect on sHUVECs. Results show that senescence induces major changes in the transcriptome of HUVECs. MRME downregulates TNF-α signaling genes in sHUVECs restoring the expression to that observed in yHUVECs. Genome-wide DNA methylation analysis performed using the Oxford-Nanopore sequencing platform did not reveal significant changes in DNA methylation levels induced by MRME. Our preliminary results provide additional evidence suggesting that MRME exerts anti-inflammatory and anti-aging effects, which may be mediated by the modulation of the expression of inflammaging genes via mechanisms independent of DNA methylation. These findings highlight MRME as a promising candidate for further in vivo studies aimed at exploring its clinical translational potential in counteracting inflammaging.

Indexed as

Cellular SenescenceMalusPlant ExtractsAnti-Inflammatory AgentsDNA MethylationEpigenesis, GeneticHumansHuman Umbilical Vein Endothelial CellsNutrigenomicsTranscriptomeAnti-Inflammatory AgentsPlant Extractsanti‐aginganti‐inflammatoryDNA methylationMela Rosa Marchigianatranscriptomic analysis

Identifiers

PMID41273127
PMCPMC12700053

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.