Evidence map›Paper›PMID 41273166›Full record

ArticleJournal of cosmetic dermatology2025

Exploring Microbial and Biophysical Aspects of Dry Skin: In Vivo Test of a Novel Skincare Formulation.

Camilla D'Antonio, Fabrizia Lo Bosco, Giulia Gentili, Serena Belmonte, Giulia DeMartini, Giorgia Condrò, Paola Perugini

Abstract read
In one paragraph

Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Camilla D'AntonioScientific Department, Medspa Srl, Milan, Italy.
Fabrizia Lo BoscoScientific Department, Medspa Srl, Milan, Italy.
Giulia GentiliScientific Department, Medspa Srl, Milan, Italy.
Serena BelmonteScientific Department, Medspa Srl, Milan, Italy.
Giulia DeMartiniEtichub s.r.l., Academic Spin-Off University of Pavia, Pavia, Italy.
Giorgia CondròDepartment of Drug Sciences, University of Pavia, Pavia, Italy.
Paola PeruginiEtichub s.r.l., Academic Spin-Off University of Pavia, Pavia, Italy.ORCID https://orcid.org/0000-0002-8774-8534

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDry skin is a prevalent dermatological concern influenced by environmental factors and characterized by compromised skin barrier integrity. In addition to this, skin microbiota is involved and plays a crucial role in maintaining microbial flora balance. This study aims to investigate dry skin condition and microbiota then the efficacy of a novel skincare formulation (Nourish 3-Biotic Rich Serum) containing prebiotics, probiotics and postbiotics in addressing dry skin symptoms and rebalancing skin microbiota. They are mainly microorganism lysate, together with fermented substances such as oligosaccharides, enzymes, and peptides, that support and provide nourishment to bacteria that live on the skin. MATERIALS AND

methodsSerum formula and serum placebo were tested in a single-blind study in which 20 female volunteers aged 28-65 with dry skin were enrolled. Several skin biophysical parameters related to skin barrier condition (stratum corneum water content, transepidermal water loss (TEWL), protein content), mechanical properties (R RESULTS AND

conclusionThis study highlighted that the product has proven to have a moisturizing action, exerts a cellular renewal action, improves skin firmness and elasticity, and reduces skin roughness. For microbial analysis, the main evidence is that both the placebo and the product help restore the skin microbiota but only the product increased the quantity of Cutibacterium acnes (one of the primary commensal bacteria of the skin) and was able to decrease the abundance of Pseudomonas koreensis usually associated with dry and rosacea skin with beneficial effects.

Indexed as

MicrobiotaPrebioticsProbioticsSkinSkin CareAdultAgedAge FactorsFemaleHumansMiddle AgedSingle-Blind MethodWater Loss, InsensiblePrebioticsbiophysical parametersdry skinpostbioticsprebioticsprobioticsskin microbiota

Identifiers

PMID41273166
PMCPMC12639409

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.