Evidence map›Paper›PMID 41273248›Full record

Trial reportClinical pharmacology in drug development2026

A Phase 1, Randomized, Placebo-Controlled, Multiple-Dose, Double-Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals.

Rajinder Bhardwaj, Chay Ngee Lim, Yinhua Li, Kyle T Matschke, Richard Bertz, Robert Croop, Jing Liu

Abstract readRandomized Controlled TrialClinical Trial, Phase IComparative Study
In one paragraph

Trial report in Clinical pharmacology in drug development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rajinder BhardwajCertara USA, Radnor, PA, USA.
Chay Ngee LimPfizer Inc., Cambridge, MA, USA.
Yinhua LiPfizer R&D Japan, Tokyo, Japan.
Kyle T MatschkePfizer Inc., Collegeville, PA, USA.
Richard BertzBiohaven Pharmaceuticals, New Haven, CT, USA.
Robert CroopBiohaven Pharmaceuticals, New Haven, CT, USA.
Jing LiuPfizer Inc., Groton, CT, USA.

Funding

BiohavenPfizer
6 · The paper itself

Abstract

This Phase 1, randomized, placebo-controlled, double-blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1); fold-change (expressed as geometric mean ratio) for Japanese versus Caucasian participants ranged 1.13-1.55 for maximum plasma concentration (C

Indexed as

PiperidinesPyridinesAdultArea Under CurveAsian PeopleDose-Response Relationship, DrugDouble-Blind MethodEast Asian PeopleFemaleHealthy VolunteersHumansJapanMaleMiddle AgedWhite PeopleYoung AdultPiperidinesPyridinesCaucasianJapanesepharmacokineticsPhase 1rimegepantsafety

Identifiers

PMID41273248
PMCPMC12946599

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.