ArticleGenes & genomics2026
Serotonin drives fat storage via 5-HT7 signaling in Drosophila.
Article in Genes & genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Molecular and neural mechanisms of sodium sensation.Genes & genomics · 2026Review
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Authors and funding
3 authors.
Funding
Abstract
backgroundDopamine and serotonin (5-hydroxytryptamine, 5-HT) are versatile biogenic amines implicated in various physiological functions, notably in the regulation of metabolism. In mammals, their involvement in energy homeostasis is well documented.
objectiveWhile the central roles of dopamine and serotonin are well characterized, their peripheral metabolic functions in invertebrates remain less defined. Therefore, we aimed to explore their involvement in lipid metabolism regulation in Drosophila melanogaster.
methodsLevels of carbohydrates, proteins, and lipids were quantified through spectrophotometric assays. Immunohistochemistry combined with confocal microscopy was used to assess expression patterns. Lipid droplets were stained using Nile Red to visualize lipid accumulation.
resultsLoss-of-function mutants for 5-HT7 exhibit significantly elevated triacylglycerol (TAG) levels and enlarged lipid droplets, indicating disrupted lipid homeostasis. Expression analysis shows that 5-HT7 is broadly expressed in the brain, gut, and fat body—key metabolic organs—suggesting a role in systemic metabolic signaling. Targeted knockdown of 5-HT7 in the fat body recapitulates the lipid accumulation phenotype, supporting a tissue-autonomous function in lipid regulation. Notably, dietary supplementation with metformin restores TAG levels in 5-HT7 mutants, implicating energy-sensing pathways as potential downstream effectors of serotonergic metabolic control.
conclusionThe serotonin receptor 5-HT7 functions as a central regulator of lipid storage and underscores serotonin’s broader role in inter-organ metabolic coordination, with potential implications for understanding energy homeostasis in higher organisms.
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