Evidence map›Paper›PMID 41273698›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Organoids for Genotoxicity Assessment.

Angela L Caipa Garcia, David H Phillips

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Angela L Caipa GarciaComprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK. angela.caipa_garcia@kcl.ac.uk.
David H PhillipsDepartment of Analytical, Environmental & Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, Franklin-Wilkins Building, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organoid cultures mimic the composition, structure, and function of the organ they derive from to a certain extent, providing more physiologically and biologically relevant results to humans than the currently used monolayer cell cultures and animal models. Organoids have been derived for several organs, from both pluripotent and adult stem cells, and are becoming more commonly used in different areas of research, including development, disease, and pharmacological studies. Their potential in genotoxicity assessment has been reported, although it is still at an early stage. Methods to assess gene expression changes, DNA damage, and metabolite formation have been used and are outlined here.

Indexed as

DNA DamageMutagensOrganoidsAnimalsHumansMutagenicity TestsMutagensDNA adductsDNA damageGenotoxicityMetabolitesOrganoids

Identifiers

PMID41273698

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.