ArticleSurgical endoscopy2026
Prognostic impact of different lymph node staging systems in patients with esophageal squamous cell carcinoma.
Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEsophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with poor prognosis. Accurate lymph node (LN) staging is vital for prognostication. This study compared accuracy of 5 LN staging systems for predicting long- and short-term outcomes.
methodsAn ambispective cohort study included 1803 ESCC patients who underwent esophagectomy between January 2015 and December 2016, with follow-up until July 2022. Long-term outcomes were overall survival (OS) and disease-free survival (DFS). Short-term outcomes included postoperative complications. Kaplan-Meier and log-rank tests compared survival, Cox regression assessed OS/DFS, and logistic regression analyzed complications. Prognostic accuracy was compared using Akaike Information Criterion (AIC), concordance index (C-index), and area under the curve (AUC).
resultsCox regression analysis demonstrated that pN (HR = 4.583, 95% CI 3.412-6.155), lymph node ratio (LNR) (HR = 5.234, 95% CI 3.936-6.950), log odds of positive lymph nodes (LODDS) (HR = 3.236, 95% CI 2.678-3.910), negative lymph nodes (HR = 0.686, 95% CI 0.560-0.840), and resected lymph nodes (HR = 0.791, 95% CI 0.637-0.980) were associated with OS in ESCC patients, with consistent findings observed for DFS. pN, LNR, and LODDS were associated with postoperative complications. LNR had the best long-term prognostic performance (5-year OS AUC = 0.791, 5-year DFS AUC = 0.766), while LODDS was superior for predicting short-term outcomes (AUC = 0.731).
conclusionLNR was the most accurate staging system for long-term prognosis, and LODDS best predicted short-term outcomes in ESCC. These findings may refine LN staging and prognostication in ESCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.