ArticleBMC pregnancy and childbirth2025
First-trimester atherogenic index of plasma and triglyceride-glucose indices in pregestational diabetes mellitus: associations with adverse pregnancy outcomes.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Predictive Value of the second-Trimester Triglyceride-Glucose Index and Its Derived Indices for Macrosomia in Gestational Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPregestational diabetes mellitus (PREGDM) confers a high risk of maternal and perinatal morbidity. Identifying early, reliable biomarkers is critical for risk stratification. The atherogenic index of plasma (AIP) and triglyceride–glucose (TyG) index are inexpensive metabolic markers reflecting dyslipidemia and insulin resistance, but their role in PREGDM remains underexplored.
methodsIn this retrospective cohort study, medical records of 628 women (314 with PREGDM, 314 controls) delivering at a tertiary referral center were reviewed. First-trimester fasting blood samples were analyzed to calculate AIP [log₁₀(TG/HDL-C)] and TyG [ln(TG×glucose/2)]. Maternal and perinatal outcomes assessed included preeclampsia, preterm birth, macrosomia, fetal growth restriction (FGR), NICU admission, Apgar < 7 at 1 and 5 min, and a composite adverse perinatal outcome (CAPO). Logistic regression adjusted for age, BMI, parity, smoking, HbA1c, and fasting glucose; predictive ability was evaluated by ROC analysis.
resultsCompared with controls, women with PREGDM had significantly higher AIP (0.171 ± 0.207 vs. 0.148 ± 0.029, p < 0.001) and TyG (9.33 ± 0.65 vs. 8.90 ± 0.10, p < 0.001). PREGDM was associated with higher rates of preeclampsia (13.1% vs. 4.5%), preterm birth (21.7% vs. 10.8%), macrosomia (13.4% vs. 5.7%), FGR (8.3% vs. 3.8%), NICU admission (23.6% vs. 8.9%), and CAPO (29.3% vs. 9.9%) (all p < 0.01). In multivariate models, TyG independently predicted preterm birth (OR 1.62, 95% CI 1.28–2.04), macrosomia (OR 1.48, 95% CI 1.10–1.99), CAPO (OR 1.78, 95% CI 1.35–2.33), and low Apgar at 1 min (OR 1.84, 95% CI 1.40–2.42). AIP was inversely associated with FGR (OR 0.68, 95% CI 0.51–0.92). ROC analysis showed high accuracy of TyG for predicting low Apgar at 1 min (AUC 0.88) and NICU admission (AUC 0.76).
conclusionsBoth AIP and TyG are elevated in PREGDM compared with controls. TyG is a robust predictor of preterm birth, macrosomia, neonatal compromise, and CAPO, whereas AIP provides complementary insight into vascular dysfunction and FGR in PREGDM group. These indices, easily derived from routine first-trimester tests, may offer practical tools for early obstetric risk stratification.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.