Evidence map›Paper›PMID 41275129›Full record

ArticleBMC genomics2025

Effect of induced molting on bone remodeling in laying hens.

Lujie Zhang, Zhiyuan An, Wei Li, Xinxin Liu, Enyou Zhou, Peng Cui, Yanhua Zhang, Yujie Guo, Guoxi Li, Zhuanjian Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lujie ZhangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Zhiyuan AnCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Wei LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Xinxin LiuCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Enyou ZhouCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Peng CuiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Yanhua ZhangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Yujie GuoCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Guoxi LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Zhuanjian LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Yadong TianCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Shucheng HuangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Ruirui JiangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Xiangtao KangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Ruili HanCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China. rlhan@126.com.ORCID http://orcid.org/0000-0002-3695-1647

Funding

earmarked fund for CARS No. CARS-40-K04Key Research Project of the Shennong Laboratory SN01-2022-05National Key Research and Development Program of China NO.2023YFF1001100
6 · The paper itself

Abstract

backgroundEnhancing bone quality is crucial for the health and productivity of laying hens. Fasting is a known way to cause physiological changes in layer hens, but research on skeletal changes during molting is still limited.

resultsThis study used a fasting-induced model to assess phenotypic changes and systematically investigate bone resorption and remodeling through transcriptomic analysis. During this process, serum phosphorus, ALP, PTH, and E2 levels in the resumption of feeding were significantly higher than in other groups, with BMC in the resumption of feeding also being significantly elevated. Further transcriptome sequencing of the tibia at different periods was conducted, and many differentially expressed genes, such as CCK, SHH, ENDRB, FZD4, AGT, and TRPM1, were identified. Key signaling pathways involved in bone development, such as the Wnt/β-catenin and calcium signaling pathways, were also determined.

conclusionThis adaptive response of fasting followed by refeeding helps improve bone quality in laying hens during the late laying period.

Indexed as

Bone RemodelingChickensMoltingAnimalsFastingFemaleGene Expression ProfilingTranscriptomeBone qualityBone remodelingFasting-inducedLate-laying hensRNA-sequence

Identifiers

PMID41275129
PMCPMC12750554

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.