Evidence map›Paper›PMID 41275213›Full record

ArticleThrombosis journal2025

Coagulation parameters reference interval for adult population of Debre Berhan town, Northeast Ethiopia.

Amanuel Kelem, Getabalew Engidaye, Bedasa Addisu, Befikad Mandefro, Bisrat Birke Teketelew, Dereje Mengesha Berta, Yalew Muche, Abateneh Melkamu, Zewudu Mulatie, Tiruneh Adane

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Article in Thrombosis journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Amanuel KelemDepartment of Medical Laboratory Sciences, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia. amanuelkelem@gmail.com.
Getabalew EngidayeDepartment of Medical Laboratory Science, College of Medicine and Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia.
Bedasa AddisuDepartment of Medical Laboratory Science, College of Medicine and Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia.
Befikad MandefroDepartment of Medical Laboratory Sciences, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia.
Bisrat Birke TeketelewDepartment of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Dereje Mengesha BertaDepartment of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Yalew MucheDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Abateneh MelkamuDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Zewudu MulatieDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Tiruneh AdaneDepartment of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccurate coagulation parameter reference intervals are crucial for diagnosing bleeding disorders and thromboembolic diseases. However, reference intervals vary across populations due to genetic, environmental, and demographic factors. This study aimed to establish localized coagulation reference intervals for healthy adults of Debre Berhan, Northeast Ethiopia, addressing the current reliance on non-local values.

methodsA community-based cross-sectional study was conducted in Debre Berhan, Northeast Ethiopia, from October-December 2024. We recruited 240 healthy adults (120 of each gender) using convenience sampling. Participants were interviewed face-to-face using a pre-tested questionnaire on KoBoToolbox to collect demographic data. Aseptically drawn venous blood was analyzed for coagulation parameters using Sysmex CA-104 coagulation analyzer. Stata 17 was used for data analysis, with reference intervals determined by the 2.5th and 97.5th percentiles. Gender differences were assessed using the Mann-Whitney U test (p < 0.05 significance).

resultsThe established 95% coagulation reference intervals (2.5th -97.5th percentile) were: Prothrombin time (8.5-13.0 sec), international normalized ratio (0.7-1.1), and activated partial thromboplastin time (21.6-37.9 sec). Males exhibited significantly higher median PT (10.4 Vs. 9.8 sec, p = 0.0006) and INR (0.9 Vs. 0.84, p = 0.0006) values compared to females.

conclusionThis study's findings strongly support the adoption of population-specific reference intervals to ensure accurate diagnoses and improve patient safety within the Debre Berhan adult population. The observed gender-related differences in Prothrombin time and international normalized ratio values further highlight the need for gender-specific reference intervals to improve clinical decision-making and prevent potential misinterpretations of coagulation test results.

Indexed as

Coagulation parametersDebre BerhanEthiopiaReference intervals

Identifiers

PMID41275213
PMCPMC12641885

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