Evidence map›Paper›PMID 41275494›Full record

ReviewCell reports2025

Airway immunometabolic responses during pulmonary bacterial and viral infections.

Ridhima Wadhwa, Eric Tang, Lok Yin Roy Wong, Tania Wong Fok Lung

Abstract readReview
In one paragraph

Review in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ridhima WadhwaCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07101, USA.
Eric TangCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07101, USA.
Lok Yin Roy WongCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07101, USA; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA; Center for Virus-Host Innate Immunity, Rutgers New Jersey Medical School, Newark, NJ 07101, USA. Electronic address: roy.wong@rutgers.edu.
Tania Wong Fok LungCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07101, USA; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA. Electronic address: tania.wong@rutgers.edu.

Funding

Understanding the Metabolic Regulation of Immune Responses to Bacterial InfectionsR35GM160393 · NIGMS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI WONG FOK LUNG, TANIA · 2025 to 2025
$2.2M
Understanding the immunometabolic response to Klebsiella pneumonia infectionR00HL157550 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Tania Wong Fok Lung · 2024 to 2026
$747k
Phenotypic and functional characterization of Betacoronavirus Internal protein in relation to virulenceR00AI170996 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI WONG, LOK-YIN ROY · 2024 to 2025
$498k
NHLBI NIH HHS R00 HL157550NIAID NIH HHS R00 AI170996NIGMS NIH HHS R35 GM160393
6 · The paper itself

Abstract

Airway infections caused by viral and bacterial pathogens pose a significant threat to human health, with the COVID-19 pandemic serving as a stark reminder of their detrimental impact. This review explores the critical role of metabolism in determining the outcome of respiratory infections. It covers fundamental concepts in immunometabolism and details how common pathogens exploit the host metabolism to dysregulate immune responses or evade immune clearance. We further consider how immune-signaling metabolites can directly drive pathogen evolution, emphasizing the importance of a better understanding of host-pathogen metabolic interactions in developing effective new therapies.

Indexed as

Bacterial InfectionsCOVID-19LungRespiratory Tract InfectionsVirus DiseasesAnimalsHost-Pathogen InteractionsHumansSARS-CoV-2CP: immunologyCP: metabolism

Identifiers

PMID41275494
PMCPMC12882823

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.