Evidence map›Paper›PMID 41276278›Full record

ArticleObesity (Silver Spring, Md.)2026

Sex-Specific Subcutaneous Adipose Tissue Transcriptome in Obesity: Insights From Monozygotic Twin Pairs Discordant for BMI.

Hanna Haltia, Maheswary Muniandy, Sini Heinonen, Sina Saari, Marcus Alvarez, Antti Hakkarainen, Jesper Lundbom, Juho Kuula, Per-Henrik Groop, Jaakko Kaprio and 3 more

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hanna HaltiaObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0001-8750-8998
Maheswary MuniandyObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0001-7624-7948
Sini HeinonenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-6342-0577
Sina SaariObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Marcus AlvarezDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Antti HakkarainenHUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Jesper LundbomHUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Juho KuulaHUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Per-Henrik GroopFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Jaakko KaprioInstitute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.
Päivi PajukantaDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Kirsi H PietiläinenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-8522-1288
Birgitta W van der KolkObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0001-8608-541X

Funding

Finnish Diabetes Research FoundationFinnish Foundation for Cardiovascular ResearchFinnish Medical FoundationGovernment Research FundsGyllenberg FoundationHelsinki University HospitalNovo Nordisk Foundation NNF10OC1013354Novo Nordisk Foundation NNF17OC0027232Novo Nordisk Foundation NNF20OC0060547Novo Nordisk Foundation NNF23SA0083953Novo Nordisk Foundation NNF24SA0090438Novo Nordisk Foundation NNF25OC0100827Orion Research Foundation srPaavo Nurmi FoundationPaulo FoundationResearch Council of Finland 263278Research Council of Finland 265240Research Council of Finland 266286Research Council of Finland 272376Research Council of Finland 308248Research Council of Finland 312073Research Council of Finland 314383Research Council of Finland 335443Research Council of Finland 338417Research Council of Finland 352792Research Council of Finland 361956Sigrid Jusélius FoundationUniversity of HelsinkiYrjö Jahnsson Foundation
6 · The paper itself

Abstract

objectiveWe investigated the impact of sex on the subcutaneous adipose tissue (AT) transcriptome and its obesity-related adaptations.

methodsWe studied rare BMI-discordant monozygotic twin pairs (ΔBMI > 2.5 kg/m

results(1) AT transcriptional profiles differed between sexes, associating with insulin sensitivity. (2) Sex-stratified obesity effects within pairs were stronger in females, with upregulated inflammation and downregulated mitochondrial oxidative phosphorylation; males showed increased inflammation and decreased histone modification. (3) The response to obesity was sex-specific: lower expression of genes in unsaturated fatty acid metabolism in obesity was seen in females only. Sex-specific obesity AT gene expression was associated with metabolic health, with a negative association between unsaturated fatty acid metabolism and insulin sensitivity in males only.

conclusionsBiological sex influences the AT transcriptome and its response to obesity, highlighting distinct molecular mechanisms that may contribute to sex-specific metabolic health.

Indexed as

ObesitySubcutaneous FatTranscriptomeTwins, MonozygoticAdultBody Mass IndexFemaleHumansInsulin ResistanceMaleMiddle AgedSex Factorsadipose tissuemonozygotic twinsobesitysex differencestranscriptome

Identifiers

PMID41276278
PMCPMC12850595

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.