ArticleAbdominal radiology (New York)2026
Could CT spleen volumetry be a novel biomarker for predicting renal graft function?
Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate whether spleen volume and its changes on imaging could serve as novel, noninvasive biomarker and predictor of renal graft function within the first post-transplant year, and to compare their prognostic performance with conventional imaging parameters such as the renal artery resistive index (RI) for predicting graft function decline. MATERIAL AND
methodThis retrospective study included 76 renal transplant recipients who had preoperative and 6-month postoperative non-contrast abdominal CT and renal Doppler ultrasonography. Spleen and graft volumes were measured volumetrically on CT, while RI was recorded at 1 and 6 months postoperatively. Changes in RI and spleen/graft volumes were calculated. Glomerular filtration rate at months 1 and 12 was used to determine graft function decline, defined as a ≥ 10 mL/min/1.73 m² GFR decrease. Associations between these parameters were analyzed using non-parametric statistics.
resultsPatients with graft function decline exhibited higher preoperative (p = 0.020) and 6-month RI (p = 0.030) values and greater RI changes (p = 0.010). Also, these patients had smaller preoperative spleen volumes (p = 0.021). Patients with decreasing follow-up spleen volume at months 6 had poorer graft function at months 12 (p = 0.004). Graft volume and its change showed no significant association with graft function.
conclusionSpleen volume changes could reflect heightened systemic immune activation and limited immunologic reserve for renal transplant patients. This highlights the underrecognized bridging radiologic and immunologic role of the spleen as imaging biomarker into post-transplant immunodynamics. Routine CT spleen volumetry could offer a novel, easily accessible predictor of renal allograft function decline within first year-redefining the role of spleen in immune monitoring after renal transplantation.
Indexed as
Identifiers
41276639What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.