Evidence map›Paper›PMID 41276702›Full record

SynthesisOral and maxillofacial surgery2025

Clinicopathological profile of clear cell oral squamous cell carcinoma: a systematic review.

Moisés Willian Aparecido Gonçalves, Iara Vieira Ferreira, Tayná Figueiredo Maciel, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Oral and maxillofacial surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Moisés Willian Aparecido Gonçalves *Department of Pathology, School of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Tessália Vieira de Camargo, 126 - Barão Geraldo, Cidade Universitária, Campinas, São Paulo, SP, 13083-887, Brazil.
Iara Vieira Ferreira *Department of Pathology, School of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Tessália Vieira de Camargo, 126 - Barão Geraldo, Cidade Universitária, Campinas, São Paulo, SP, 13083-887, Brazil.
Tayná Figueiredo MacielDepartment of Pathology, School of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Tessália Vieira de Camargo, 126 - Barão Geraldo, Cidade Universitária, Campinas, São Paulo, SP, 13083-887, Brazil.
Erika Said Abu EgalBiorepository and Molecular Pathology, Huntsman Cancer Institute, University of Utah (UU), Salt Lake City, UT, USA.
Albina AltemaniDepartment of Pathology, School of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Tessália Vieira de Camargo, 126 - Barão Geraldo, Cidade Universitária, Campinas, São Paulo, SP, 13083-887, Brazil.
Fernanda Viviane MarianoDepartment of Pathology, School of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Tessália Vieira de Camargo, 126 - Barão Geraldo, Cidade Universitária, Campinas, São Paulo, SP, 13083-887, Brazil. fmariano@unicamp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn this systematic review, we aimed to evaluate the clinicopathological profile of clear cell oral squamous cell carcinoma (CCOSCC). STUDY

designA detailed search was carried out in PubMed, Scopus, EMBASE, LILACS, Web of Science, and Gray Literature sources.

resultsSeventeen cases of CCOSCC were found across 16 selected articles. CCOSCC affected mainly the mandibular gingiva, maxillary gingiva, and tongue of adults with a mean age of 60.1 years old, with a slight preference for males. The cases usually manifested as painful ulcerated lesions. Microscopically, they were lined by squamous epithelium that invaded the adjacent connective tissue and contained cells with abundant clear cytoplasm. Immunohistochemical staining was performed in 15 studies, with AE1/AE3, EMA, and CK5/6 most frequently markers showing positivity. Histochemistry/special stains were used in all cases.

conclusionsThis review showed that CCOSCC is a rare and aggressive tumor with a slight predilection for male patients, located mainly in the mandibular gingiva, maxillary gingiva, and tongue.

Indexed as

Carcinoma, Squamous CellMouth NeoplasmsGingival NeoplasmsHumansMaleMiddle AgedClear cell oral squamous cell carcinomaClear cell variantSquamous cell carcinomaSystematic review

Identifiers

PMID41276702

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.