Evidence map›Paper›PMID 41276737›Full record

ArticleMolecular neurobiology2025

Protein Phosphatase 1 Regulatory Subunit 17 (PPP1R17) Regulates Cerebral Ischemia and Ischemia-Reperfusion Brain Injury by Suppressing YAP1-Mediated Mitophagy.

Ming Ma, Jiahui Yang, Zheng Li, Xiaohua Shi, Zhongxin Xu

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ming MaDepartment of Neurology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, Jilin, China.
Jiahui YangDepartment of Neurology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, Jilin, China.
Zheng LiDepartment of Neurology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, Jilin, China.
Xiaohua ShiDepartment of Neurology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, Jilin, China. shixh0915@jlu.edu.cn.
Zhongxin XuDepartment of Neurology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, Jilin, China. xuzhongxin@jlu.edu.cn.

Funding

Natural Science Foundation of Jilin Province YDZJ202401444ZYTS
6 · The paper itself

Abstract

Stroke is a vital cause of death worldwide. Ischemic stroke, a predominant type, is characterized by a sudden blockage of blood vessels supplying the brain, causing loss of blood flow. Restoring blood flow and oxygen in ischemic areas is the principal clinical treatment for ischemic stroke. Nevertheless, this process brings cerebral ischemia-reperfusion injury, which restrains the therapeutic effect on ischemic stroke. Plumbing the pathogenesis of brain injury and ischemia-reperfusion injury induced by ischemic stroke is crucial for improving stroke treatment. In this study, we analyzed differentially expressed genes in the penumbra of ischemic and ischemia-reperfusion rat brain tissue using transcriptome sequencing and screened out a gene PPP1R17 associated with mitophagy. We found that cerebral ischemia and ischemia-reperfusion induced PPP1R17 aggravated brain injury by repressing mitophagy. Mechanistically, PPP1R17 induces YAP1 phosphorylation by limiting the phosphatase activities of PP1 and PP2A and inhibits the activation of Pink1 and Parkin transcription by YAP1 as a transcriptional coregulator. In conclusion, PPP1R17 may serve as a potential therapeutic target for ameliorating cerebral ischemia and cerebral ischemia-reperfusion induced brain injury.

Indexed as

Adaptor Proteins, Signal TransducingBrain IschemiaMitophagyReperfusion InjuryAnimalsMalePhosphorylationProtein KinasesRatsRats, Sprague-DawleyUbiquitin-Protein LigasesYAP-Signaling ProteinsAdaptor Proteins, Signal Transducingparkin proteinProtein KinasesUbiquitin-Protein LigasesYap1 protein, ratYAP-Signaling ProteinsBrain injuryCerebral ischemiaCerebral ischemia–reperfusionMitophagyProtein phosphatase 1 regulatory subunit 17Yes1-associated transcriptional regulator

Identifiers

PMID41276737

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.