ReviewJournal of extracellular vesicles2025
The Role of Extracellular Vesicles in Musculoskeletal Diseases.
Review in Journal of extracellular vesicles, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Bone targeted microenvironment actuated engineered exosomes for precision therapy of IBD associated bone loss.Bioactive materials · 2026Article
- Vesicular Communication in the Bone-Muscle Unit: Physiological Functions, Aging, and Therapeutic Potential.Cells · 2026Review
- Camouflage Protein-Engineered Extracellular Vesicles Alleviate TMJ-OA by Hijacking Caspase-1 to Suppress Pyroptosis.Journal of extracellular vesicles · 2026Article
- State-of-the-Art and Next Generation Intra-Articular Implantable Biosensors for Osteoarthritis: From Analytical Limits to Operational Stability.Biosensors · 2026Review
- Extracellular Vesicles in Osteonecrosis of the Femoral Head: An Integrated Review of Experimental and Bioinformatic Evidence.Journal of personalized medicine · 2026Review
- Effects and Molecular Mechanisms of Heat-Killed PostbioticInternational journal of molecular sciences · 2026Article
- The Role of Extracellular Vesicles in Musculoskeletal Diseases.Journal of extracellular vesicles · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Extracellular Vesicles (EVs), nanoscale membrane-bound cell-released structures, are vital for intercellular communication and material transport. Their role in musculoskeletal health and diseases has recently drawn significant attention. This review focuses on the latest EV research in musculoskeletal diseases, including their roles in disease progression and potential as biomarkers and therapies. Musculoskeletal disorders are the third-leading cause of global disability-adjusted life-years among adolescents and young adults. Current treatments face issues like limited tissue regeneration and poor drug targeting. With their natural messenger function and low immunogenicity, EVs have become a research focus. However, their action mechanisms in the musculoskeletal system remain un-systematically understood. This paper reviews EVs' role in musculoskeletal diseases. It covers classification, biogenesis, release, internalization, cargo and their involvement in muscle cell processes, joint diseases, bone metabolism and disc degeneration. It also explores EVs' role in musculoskeletal crosstalk and their potential as therapeutic agents and drug carriers through engineering with biomaterials. Future research should delve deeper into EV action mechanisms for better treatments. Overall, while EVs offer new treatment strategies for musculoskeletal diseases, more research is needed to overcome technical and clinical barriers.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.