Evidence map›Paper›PMID 41277089›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

High-Concentration Antibody Formulation via Solvent-Based Dehydration.

Talia Zheng, Lucas Attia, Janet Teng, Patrick S Doyle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. High-Concentration Antibody Formulation via Solvent-Based Dehydration.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Talia ZhengDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.ORCID https://orcid.org/0009-0006-0814-1344
Lucas AttiaDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.ORCID https://orcid.org/0000-0002-9941-3846
Janet TengDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.ORCID https://orcid.org/0000-0002-3239-5778
Patrick S DoyleDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.ORCID https://orcid.org/0000-0003-2147-9172

Funding

Advanced Scientific Computing Research DE-SC0022158MIT Department of Chemical EngineeringMIT Undergraduate Research Opportunities Program
6 · The paper itself

Abstract

Although subcutaneous (SC) delivery is the preferred administration route for immunotherapies and other biologics for improved patient compliance and lower healthcare costs, it necessitates high-concentration antibody formulations. However, high-concentration antibody solutions face significant instabilities and prohibitively high viscosities. Other approaches for high-concentration formulations have been developed, including non-aqueous solutions, which can be irritating or painful, and antibody-laden hydrogel microparticles, which require centrifugation and are limited to concentrations <300 mg mL

Indexed as

AntibodiesSolventsDesiccationHydrogelsParticle SizeWaterAntibodiesHydrogelsSolventsWateramorphous materialsantibodyhydrogelsprecipitationsubcutaneous administration

Identifiers

PMID41277089
PMCPMC12862716

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.