ReviewCancer medicine2025
Metal-Organic Frameworks Against Tumor Metastasis: Therapeutic Targets, Strategies, and Challenges for Clinical Translation.
Review in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Metal-organic frameworks-mediated reactive oxygen species modulation in the tumor microenvironment of digestive system malignancies: latest advances.Frontiers in chemistry · 2026Review
- Metal-Organic Frameworks Against Tumor Metastasis: Therapeutic Targets, Strategies, and Challenges for Clinical Translation.Cancer medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Tumor invasion and metastasis are the primary causes of cancer-related mortality and have a profound impact on patient prognosis. This review comprehensively examines the application of Metal-Organic Frameworks (MOFs) in anti-metastatic therapy and establishes a theoretical foundation for their clinical translation. A systematic literature analysis clarifies the structural and therapeutic profile of MOFs. These materials show significant promise for anti-metastatic therapy, leveraged by their high loading capacity, tunable responsiveness, and modifiable surface properties. This review discusses MOF-based multi-targeted strategies to combat metastasis, including tumor microenvironment modulation, targeting of key metastatic cells, and multimodal synergistic therapies. These approaches have demonstrated success in applications such as drug delivery, photodynamic therapy, and immune activation. The discussion further addresses critical challenges in biosafety and targeting efficiency for clinical translation, while recognizing how MOFs' structural versatility sustains their therapeutic development. This reviewaims to provide a theoretical foundation and practical framework for the innovative design and clinical translation of MOFs in anti-metastatic therapy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.