ArticleInfection and immunity2025
Comparison of cytokine responses to group B
Leslie A Kirk, Hannah A Richards, Danyvid Olivares-Villagómez, Andrea Locke, Anthony R Flores, Shannon D Manning, David M Aronoff, Kevin G Osteen, David E Cliffel, Alison J Eastman and 1 more
Abstract readComparative Study
In one paragraphArticle in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Leslie A KirkDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Hannah A RichardsDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
Danyvid Olivares-VillagómezDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Andrea LockeDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
Anthony R FloresDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-6402-4269 Shannon D ManningDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0001-9581-0660 David M AronoffDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Kevin G OsteenDepartment of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
David E CliffelDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
Alison J Eastman *Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-4296-2916 Jennifer A Gaddy *Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-2192-4224 Funding
TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7MInstrumenting the Fetal Membrane on a ChipR01HD102752 · NICHD · VANDERBILT UNIVERSITY · PI CLIFFEL, DAVID E · 2020 to 2023
$2.5MUtility of human milk oligosaccharides against the perinatal pathogen, Group B StreptococcusR01HD113675 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jennifer A Gaddy, Steven D. Townsend · 2024 to 2026
$1.1MBLRD VA I01 BX005352Burroughs Wellcome Fund 1275387Department of Veterans Affairs Office of Research Merit Review Award I01BX005352-01March of Dimes Foundation 6-FY24-0009NICHD NIH HHS R01 HD102752NICHD NIH HHS R01 HD113675NIEHS NIH HHS T32 ES007028NIH HHS 1R01HD113675NIH HHS R01HD102752NIH HHS T32 ES007028
6 · The paper itselfAbstract
Adverse pregnancy outcomes represent a global health burden. Bacterial infection and subsequent inflammation in gestational membranes lead to immunological and physiological changes that contribute to adverse pregnancy outcomes. Although animal models of infection during pregnancy are useful to interrogate tissue and cellular level changes in host responses, these models also have numerous drawbacks, including cost, complexity, and ethical considerations. The advent of organ-on-a-chip models provides cutting-edge new approaches to model host-pathogen interactions in multicellular organ and tissue environments. In this work, we employ an organ-on-a-chip model of the maternal-fetal interface as a tool to study immunological responses to infection with the perinatal pathogen, Group B
Indexed as
CytokinesExtraembryonic MembranesLab-On-A-Chip DevicesPregnancy Complications, InfectiousStreptococcal InfectionsStreptococcus agalactiaeFemaleHost-Pathogen InteractionsHumansMicrophysiological SystemsPregnancyCytokinesbacteriagestational membranespregnancyreproductive immunologyStreptococcus
Identifiers
PMID41277827
PMCPMC12707140
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