Evidence map›Paper›PMID 41277892›Full record

ArticleBone reports2025

Scavenging methylglyoxal improves bone quality and defect healing in diabetic mice.

Toshifumi Hikichi, Kumi Kimura, Seiichi Munesue, Yu Oshima, Ai Harashima, Tomo Hamada, Kanu Shimokawa, Yuki Fushitani, Hisanori Goto, Hiroyuki Tsuchiya and 3 more

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Article in Bone reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Toshifumi HikichiDepartment of Orthopedic Surgery, Kanazawa University, Kanazawa, Japan.
Kumi KimuraDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Seiichi MunesueDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Yu OshimaDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Ai HarashimaDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Tomo HamadaDepartment of Orthopedic Surgery, Kanazawa University, Kanazawa, Japan.
Kanu ShimokawaDepartment of Orthopedic Surgery, Kanazawa University, Kanazawa, Japan.
Yuki FushitaniDepartment of Orthopedic Surgery, Kanazawa University, Kanazawa, Japan.
Hisanori GotoDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Hiroyuki TsuchiyaDepartment of Orthopedic Surgery, Kanazawa University, Kanazawa, Japan.
Satoru DemuraDepartment of Orthopedic Surgery, Kanazawa University, Kanazawa, Japan.
Hidenori MatsubaraDepartment of Orthopedic Surgery, Kanazawa University, Kanazawa, Japan.
Yasuhiko YamamotoDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperglycemia in diabetes leads to the formation of methylglyoxal (MG) and accumulation of advanced glycation end-products (AGEs). We previously reported that exogenous MG exposure deteriorated osteoblastic differentiation in vitro and diabetic mice showed delayed bone defect healing along with elevated MG-derived AGE levels. However, whether endogenously formed MG is involved in impaired bone repair and remodeling in diabetes remains unclear. In this study, we investigated the effects of hyperglycemia-induced MG formation on bone quality and defect healing in mice. Using a synthetic MG probe [Ir(ppy)

Indexed as

Impaired defect healingMethylglyoxalPyridoxamineT1DM

Identifiers

PMID41277892
PMCPMC12629923

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.