Evidence map›Paper›PMID 41277896›Full record

ArticleBrain communications2025

Shape analysis of the amygdala, hippocampus and thalamus in former American football players.

Omar John, Alana Wickham, Leonard B Jung, Anya S Mirmajlesi, Jared Stearns, Katherine Breedlove, Nicholas Kim, Daniel H Daneshvar, Tashrif Billah, Ofer Pasternak and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Omar JohnDepartment of Rehabilitation Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA.ORCID https://orcid.org/0009-0008-3745-7270
Alana WickhamPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Leonard B JungPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.ORCID https://orcid.org/0009-0004-2125-5923
Anya S MirmajlesiDepartment of Rehabilitation Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA.
Jared StearnsDepartment of Rehabilitation Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA.ORCID https://orcid.org/0009-0002-5326-2090
Katherine BreedloveCenter for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0003-4408-3728
Nicholas KimPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Daniel H DaneshvarDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA 02115, USA.
Tashrif BillahPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Ofer PasternakPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Arushi ChamariaPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Michael J ColemanPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Yorghos TripodisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.ORCID https://orcid.org/0000-0003-2190-7608
Charles H AdlerDepartment of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.ORCID https://orcid.org/0000-0002-1045-2743
Charles BernickCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV 89106, USA.
Laura J BalcerDepartment of Neurology, NYU Grossman School of Medicine, New York, NY 10016, USA.
Richard Jarrett RushmorePsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Michael L AloscoDepartment of Neurology, Boston University Alzheimer's Disease Research Center and CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID https://orcid.org/0000-0002-8113-8428
Inga K KoertePsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.ORCID https://orcid.org/0000-0003-1281-9286
Alexander P LinCenter for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Jeffrey L CummingsChambers-Grundy Center for Transformative Neuroscience, Pam Quirk Brain Health and Biomarker Laboratory, Department of Brain Health, Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Eric M ReimanBanner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, AZ 85006, USA.
Robert A SternDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
Martha E ShentonPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Hector ArciniegaDepartment of Rehabilitation Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA.ORCID https://orcid.org/0000-0002-5565-9633
Sylvain BouixDepartment of Software Engineering and Information Technology, École de Technologie Supérieure, Université du Québec, Montréal, QC, H3C 1K3, Canada.
DIAGNOSE CTE Research Project

Funding

Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk FactorsU01NS093334 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CUMMINGS, JEFFREY L., REIMAN, ERIC MICHAEL · 2016 to 2022
$17.0M
Sex Differences in Brain Structure and Function After Sports-Related ConcussionR01NS100952 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI KOERTE, INGA KATHARINA · 2017 to 2022
$2.9M
Understanding the Neuroanatomical Abnormalities of Repetitive Head ImpactsR21NS140565 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Hector Arciniega · 2025 to 2026
$466k
Understanding the Cognitive and Neural Consequences of Repetitive Head ImpactsK00NS113419 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI ARCINIEGA, HECTOR · 2020 to 2022
$265k
NINDS NIH HHS K00 NS113419NINDS NIH HHS R01 NS100952NINDS NIH HHS R21 NS140565NINDS NIH HHS U01 NS093334
6 · The paper itself

Abstract

Repetitive head impacts are common in contact and collision sports and are linked to structural brain changes and an elevated risk of neurodegenerative diseases such as Chronic Traumatic Encephalopathy. Identifying early in vivo structural markers remains challenging. Although diagnosis currently requires post-mortem confirmation, clinical symptoms, including cognitive impairment and behavioural changes, are reflected in the diagnosis of Traumatic Encephalopathy Syndrome. These symptoms align with dysfunction in key brain regions-amygdala, hippocampus and thalamus-which support memory, emotion and behaviour and commonly show tau pathology in Chronic Traumatic Encephalopathy. This study uses shape analysis to examine structural differences in these regions between former American football players and unexposed asymptomatic controls and evaluates the influence of age, head impact exposure and clinical diagnosis on brain structure. We analyzed brain morphology in former American football players (

Indexed as

neuroimagingrepetitive head impactsshape analysissports-related head injurystructural MRI

Identifiers

PMID41277896
PMCPMC12631119

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.