ReviewInternational journal of general medicine2025
The Model of Neutrophil Chemotaxis Participated by the Vascular Endothelial Glycocalyx.
Review in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vascular endothelial glycocalyx is a critical structural and functional component. It maintains endothelial integrity, orchestrates hemodynamic regulation, enables selective blood component filtration, and mediates mechanotransduction. Existing in a dynamic equilibrium, this glycoprotein-polysaccharide matrix provides an interactive platform for intravascular reactions and actively participates in innate immune responses (eg, neutrophil chemotaxis and adhesion). During localized tissue infection, pathogen-derived chemokines become enriched within the endothelial glycocalyx, establishing a chemotactic gradient that directs neutrophil recruitment. Intriguingly, neutrophil-derived proteolytic enzymes and reactive oxygen species released during degranulation reciprocally degrade the glycocalyx architecture, thereby amplifying chemokine liberation and creating a self-reinforcing feedback loop that potentiates neutrophil extravasation and directional migration. This review systematically analyzes two distinct mechanistic models elucidating the dual role of the endothelial glycocalyx in neutrophil chemotaxis. These conceptual frameworks advance our understanding of the spatiotemporal regulation of innate immune responses at the vascular interface while highlighting potential therapeutic targets for inflammatory disorders associated with glycocalyx dysfunction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.