Evidence mapPaperPMID 41278447Full record

ArticleWorld journal of diabetes2025

Real-world evidence for herbal medicine benefit in 9728 type 2 diabetes patients-peridonotitis risk and ambulatory care utilization.

Wen-Wei Lin, Chieh-Tsung Yen, Hanoch Livneh, Hua-Lung Huang, Ming-Chi Lu, Wei-Jen Chen, Tzung-Yi Tsai

Abstract read
In one paragraph

Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wen-Wei LinGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 333325, Taiwan.
Chieh-Tsung YenDepartment of Neurology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.
Hanoch LivnehRehabilitation Counseling Program, Portland State University, Portland, OR 97207, United States.
Hua-Lung HuangDepartment of Rehabilitation, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.
Ming-Chi LuSchool of Medicine, Tzu Chi University, Hualien 97050, Taiwan.
Wei-Jen ChenGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 333325, Taiwan.
Tzung-Yi TsaiDepartment of Medical Research, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent evidence manifests that individuals with type 2 diabetes (T2D) are increasingly affected by oral disorders. Although medicinal herbs have shown promise in managing T2D, their benefit in managing periodontitis risk and subsequent healthcare utilization remains uncertain.

aimTo compare risk of periodontitis and associated ambulatory care utilization among individuals with T2D who did or did not receive add-on medicinal herbs.

methodsWe included individuals aged 20-70 years with newly diagnosis of T2D and being free of periodontitis in 2000 and 2010. Periodontitis events were tracked from cohort entry until December 31, 2013. The association between medicinal herb use and periodontitis risk was assessed by multivariate Cox regression, while differences in periodontitis-related ambulatory care were analyzed using Mann-Whitney

resultsAfter propensity score matching, 9728 individuals were included in both the herbal and non-herbal groups. Those who used herbs for more than two years experienced a potently lower risk of periodontitis by 52%. Compared to herb users, the non-users substantially incurred higher frequency and cost of periodontitis-related ambulatory visits post-diagnosis, and the costs per ambulatory visit increased with time after periodontitis onset.

conclusionThe rollout of this study not only tackled the former research gap but also provided an insight that the combination of medicinal herbs may take into account while planning holistic and individualized oral health care for T2D persons.

Indexed as

Cohort studyInterdisciplinary collaborationMedicinal herbsPeriodontitisRiskType 2 diabetes

Identifiers

PMID41278447
PMCPMC12635765

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.