Evidence mapPaperPMID 41278449Full record

ReviewWorld journal of diabetes2025

Mechanisms behind the anti-diabetic and anti-obesity effects of seaweeds or macroalgae and their bioactive compounds.

S'thandiwe Nozibusiso Magwaza, Md Shahidul Islam

Abstract readReview
In one paragraph

Review in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Edible Marine Red AlgaFoods (Basel, Switzerland) · 2026
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

S'thandiwe Nozibusiso MagwazaDepartment of Biochemistry, University of KwaZulu-Natal, Durban 4000, KwaZulu-Natal, South Africa.
Md Shahidul IslamDepartment of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Durban 4000, KwaZulu-Natal, South Africa. islamd@ukzn.ac.za.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity and diabetes have become global health crises, with rising prevalence and a strong association with various chronic diseases such as cardiovascular disease, stroke, and certain cancers. These conditions contribute to significant morbidity and mortality, highlighting the urgent need for effective therapeutic interventions. Marine products, including fish oils and marine plants, have been increasingly recognized for their potential in mitigating these diseases. Among these, seaweed stands out due to their diverse bioactive compounds and promising therapeutic effects. This comprehensive review explores the mechanisms of action through which seaweeds, and their compounds exert anti-diabetic and anti-obesity effects, including the regulation of adipogenesis, appetite control, modulation of gut microbiota, enhancement of insulin sensitivity, and reduction of inflammation, oxidative stress, and β-cell dysfunction. Despite the promising potential, challenges such as variability of bioactive compounds and low bioavailability remain there. Advances in bioactive delivery systems and along with large-scale clinical trials, are crucial for optimizing the therapeutic use of bioactive compounds from seaweeds. Future research should also explore synergistic strategies combining seaweed compounds with other bioactive substances. Overall, seaweed offers a promising foundation for developing functional foods and nutraceuticals aimed at promoting long-term metabolic health, providing an innovative approach to addressing obesity and diabetes.

Indexed as

Bioactive compoundsDiabetesGut microbiotaInflammationInsulin sensitivityLipogenesisMacroalgaeObesityOxidative stressSeaweeds

Identifiers

PMID41278449
PMCPMC12635779

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.