ArticleResearch and practice in thrombosis and haemostasis2025
Stroke severity and other predictors of venous thromboembolism in stroke patients-a population-based cohort study.
Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Venous thromboembolism (VTE) frequently occurs after stroke, particularly within the first 3 months after diagnosis. Poststroke VTE is associated with increased mortality. Stroke severity is a known predictor of adverse prognosis; however, its ability to predict VTE is unclear. Knowledge regarding other predictors of poststroke VTE is lacking. Objectives: To identify clinical predictors of poststroke VTE in the subacute and acute phases, and to assess the association between stroke severity and poststroke VTE. Methods: In a population-based cohort study, we identified patients (aged ≥18 years and without recent VTE) with first-time ischemic stroke ( Results: In the subacute phase, 1016 (0.8%) patients developed VTE after ischemic stroke, and 200 (1.2%) patients developed VTE after intracerebral hemorrhage. In univariable analyses, VTE risk was 2- to 5-fold higher in those with severe stroke, active cancer, and previous VTE. These findings were consistent for both stroke subtypes and follow-up periods. Multivariable analyses showed no substantial alterations in the estimates for stroke severity. Conclusion: Stroke severity, active cancer, and previous VTE strongly predict poststroke VTE in patients in the subacute and acute phases. These findings offer valuable insights and can be used to identify patients at elevated risk of VTE in whom extended thromboprophylaxis may be considered.
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