Evidence map›Paper›PMID 41278499›Full record

ArticleNanoscale advances2026

Dexamethasone-loaded lipid-polymeric nanoparticles to improve therapy for cisplatin-induced sensorineural hearing loss.

Wang Qi, Huang Qiling, Li Liling, Li Zhicheng, Li Peng, Zeng Xiangli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wang QiDepartment of Otorhinolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University 600 Tianhe Road, Tianhe District 510000 Guangzhou Guangdong China zxiangl@mail.sysu.edu.cn lipeng25@mail.sysu.edu.cn.ORCID https://orcid.org/0000-0001-7478-4408
Huang QilingDepartment of Otorhinolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University 600 Tianhe Road, Tianhe District 510000 Guangzhou Guangdong China zxiangl@mail.sysu.edu.cn lipeng25@mail.sysu.edu.cn.
Li LilingDepartment of Otorhinolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University 600 Tianhe Road, Tianhe District 510000 Guangzhou Guangdong China zxiangl@mail.sysu.edu.cn lipeng25@mail.sysu.edu.cn.
Li ZhichengDepartment of Otorhinolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University 600 Tianhe Road, Tianhe District 510000 Guangzhou Guangdong China zxiangl@mail.sysu.edu.cn lipeng25@mail.sysu.edu.cn.
Li PengDepartment of Otorhinolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University 600 Tianhe Road, Tianhe District 510000 Guangzhou Guangdong China zxiangl@mail.sysu.edu.cn lipeng25@mail.sysu.edu.cn.
Zeng XiangliDepartment of Otorhinolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University 600 Tianhe Road, Tianhe District 510000 Guangzhou Guangdong China zxiangl@mail.sysu.edu.cn lipeng25@mail.sysu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sensorineural hearing loss (SNHL), caused by ototoxic drugs like cisplatin, poses significant challenges due to its irreversible nature. Dexamethasone, a potent corticosteroid, is commonly used to mitigate SNHL but suffers from systemic side effects and poor inner ear bioavailability when administered conventionally. This study explores the potential of dexamethasone-loaded lipid-polymeric nanoparticles (LPNs) to enhance drug delivery efficiency and therapeutic outcomes. The LPNs were fabricated using stearic acid and poly (lactic-

Identifiers

PMID41278499
PMCPMC12636163

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.