Evidence map›Paper›PMID 41278503›Full record

ArticleMediators of inflammation2025

Multiple Signaling Axes (TNF-α/IL1β/IL8, TLR4/MYD88/NF-κB, and TGF-β1/ROS) Associated With Coronary Collateral Circulation of Coronary Chronic Total Occlusion in Geriatric Patients.

Yongjuan Zhao, Hualan Zhou, Ying Chen, Dianxuan Guo

Abstract read
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In one paragraph

Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yongjuan ZhaoDepartment of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, The Second People's Hospital of Huai'an, Huaian 223002, China.
Hualan ZhouDepartment of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, The Second People's Hospital of Huai'an, Huaian 223002, China.
Ying ChenDepartment of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, The Second People's Hospital of Huai'an, Huaian 223002, China.
Dianxuan GuoDepartment of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, The Second People's Hospital of Huai'an, Huaian 223002, China.ORCID https://orcid.org/0009-0006-9039-3945

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The multiple signaling axes might be concerned with the poor coronary collateral circulation (CCC). This research aimed to investigate the relationship between the poor CCC and multiple signaling axes (tumor necrosis factor-α [TNF-α]/interleukin-1β [IL1β]/IL8 pro-inflammatory cytokine signaling axis, toll-like receptor 4/myeloid differentiation factor 88/nuclear factor kappa-B [TLR4/MYD88/NF-κB] immune-inflammatory signaling axis, and transforming growth factor-β1/reactive oxygen species [TGF-β1/ROS] oxidative stress-inflammatory signaling axis) in geriatric patients with coronary chronic total occlusion (CCTO). We simultaneously assessed the expressions of multiple signaling axis markers (TNF-α, IL1β, IL8, TLR4, MYD88, NF-κB, TGF-β1, and ROS) in geriatric patients with CCTO. The CCC was scored as follows: Grade 0 (without contrast filling), Grade 1 (filling of collateral vessels with no epicardial filling), Grade 2 (partial filling of epicardial arteries), and Grade 3 (fully filling of the epicardial arteries). The CCC Grade 2 group in patients with CCTO showed decreased TNF-α, IL1β, IL8, TLR4, MYD88, NF-κB, TGF-β1, and ROS compared with CCC Grade 1 group (

Indexed as

Collateral CirculationCoronary OcclusionMyeloid Differentiation Factor 88NF-kappa BReactive Oxygen SpeciesToll-Like Receptor 4Transforming Growth Factor beta1AgedAged, 80 and overFemaleHumansInterleukin-1betaInterleukin-8MaleOxidative StressSignal TransductionInterleukin-1betaInterleukin-8MYD88 protein, humanMyeloid Differentiation Factor 88NF-kappa BReactive Oxygen SpeciesTLR4 protein, humanToll-Like Receptor 4Transforming Growth Factor beta1Tumor Necrosis Factor-alphacoronary chronic total occlusioncoronary collateral circulationgeriatric patientsmultiple signaling axes

Identifiers

PMID41278503
PMCPMC12640262

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.