Evidence map›Paper›PMID 41278681›Full record

ArticlebioRxiv : the preprint server for biology2025

Dietary sulfur amino acid restriction improves glucose homeostasis through hepatic

Andres F Ortega, Cha Mee Vang, Ferrol I Rome, Kaitlyn M Andreoni, Aiden M Phoebe, Alisa B Nelson, Peter A Crawford, James J Galligan, Stanley Ching-Cheng Huang, Curtis C Hughey

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Andres F OrtegaDivision of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-5634-924X
Cha Mee VangDivision of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN.ORCID 0009-0003-8408-3965
Ferrol I RomeDivision of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN.
Kaitlyn M AndreoniDepartment of Pharmacology and Toxicology, University of Arizona, Tucson, AZ.
Aiden M PhoebeDepartment of Pharmacology and Toxicology, University of Arizona, Tucson, AZ.
Alisa B NelsonDivision of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN.ORCID 0000-0001-7685-1803
Peter A CrawfordDivision of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN.ORCID 0000-0001-8597-4426
James J GalliganDepartment of Pharmacology and Toxicology, University of Arizona, Tucson, AZ.ORCID 0000-0002-5612-0680
Stanley Ching-Cheng HuangPelotonia Institute for Immuno-oncology, Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH.ORCID 0000-0002-6557-3737
Curtis C HugheyDivision of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN.ORCID 0000-0003-2674-7359

Funding

KETONE BODY METABOLISM AND INTEGRATED METABOLIC HOMEOSTASISR01DK091538 · NIDDK · WASHINGTON UNIVERSITY · PI CRAWFORD, PETER A · 2011 to 2024
$6.2M
POSTDOCTORAL TRAINING PROGRAM IN SAS PREVENTIONT32DA007293 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MERMELSTEIN, ROBIN J. · 1993 to 2008
$2.4M
Ketogenic Oscillations and Neurometabolic HealthspanR01AG069781 · NIA · UNIVERSITY OF MINNESOTA · PI CRAWFORD, PETER A, THYFAULT, JOHN P · 2020 to 2024
$2.3M
Glyoxalase 1 and its Role in Metabolic SyndromeR01DK133196 · NIDDK · UNIVERSITY OF ARIZONA · PI James J Galligan · 2023 to 2026
$1.8M
Hepatic Integration of Mitochondrial Oxidative Metabolism Pathways in Health and DiseaseR01DK136772 · NIDDK · UNIVERSITY OF MINNESOTA · PI Curtis Hughey · 2023 to 2026
$1.6M
NIA NIH HHS R01 AG069781NIDA NIH HHS T32 DA007293NIDDK NIH HHS R01 DK091538NIDDK NIH HHS R01 DK133196NIDDK NIH HHS R01 DK136772
6 · The paper itself

Abstract

Dietary sulfur amino acid restriction (SAAR) improves whole-body glucose homeostasis, elevates liver insulin action, and lowers liver triglycerides. These adaptations are associated with an increased expression of hepatic

Indexed as

De novo serine synthesisGlucose homeostasisLiver intermediary metabolismSulfur amino acid restriction

Identifiers

PMID41278681
PMCPMC12633052

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.