Evidence map›Paper›PMID 41278682›Full record

ArticlebioRxiv : the preprint server for biology2025

Jam2 Signaling Functions Downstream of Hand2 To Initiate The Formation Of Organ-Specific Vascular Progenitors In Zebrafish.

Martyna Griciunaite, Julius Martinkus, Sanjeeva Metikala, Ricardo DeMoya, Suman Gurung, Diandra Rufin Florat, Saulius Sumanas

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Martyna GriciunaiteDepartment of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA.
Julius MartinkusDepartment of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA.
Sanjeeva MetikalaDepartment of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA.
Ricardo DeMoyaDepartment of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA.
Suman GurungDepartment of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA.
Diandra Rufin FloratDepartment of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA.
Saulius SumanasDepartment of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA.ORCID 0000-0002-8605-6122

Funding

Role of SHE and ABL signaling in vascular tubulogenesisR01HL163161 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Saulius Sumanas · 2023 to 2026
$2.6M
Novel mechanisms of vasculogenesisR01HL153005 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI SUMANAS, SAULIUS · 2021 to 2024
$2.0M
NHLBI NIH HHS R01 HL153005NHLBI NIH HHS R01 HL163161
6 · The paper itself

Abstract

The mechanisms regulating the formation of organ-specific vasculature are still poorly understood. We have previously identified a population of late-forming endothelial progenitor cells in zebrafish embryos (termed secondary vascular field, SVF), which emerge from the lateral plate mesoderm after 24 hpf stage, after blood circulation has been initiated. Here we investigate the functional role of SVF cells and the molecular mechanisms that govern the emergence of these SVF cells and their contribution to vasculature. We identified that the bHLH transcription factor Hand2 and Junctional Adhesion Molecule Jam2b are expressed in the SVF-forming region and are required for the emergence of SVF cells in zebrafish embryos. Time-lapse imaging and

Identifiers

PMID41278682
PMCPMC12632548

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.