Evidence map›Paper›PMID 41278710›Full record

ArticlebioRxiv : the preprint server for biology2025

A splice-switching antisense oligonucleotide approach for pediatric genetic epilepsies.

Haley B Dame, Hema Kopalle, Belen Miñana, Zin Klaft, Jaclyn B Fahey, David C McWatters, Vama Rao, Rushil Suresh, Stefan Aigner, Michael F Hammer and 12 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Haley B DameGenetics, Molecular and Cell Biology Program, Tufts University School of Medicine, Boston, MA, United States.
Hema KopalleDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, United States.ORCID 0000-0002-1872-7318
Belen MiñanaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.
Zin KlaftDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, United States.ORCID 0000-0002-8208-7263
Jaclyn B FaheyDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, United States.ORCID 0009-0005-4215-1581
David C McWattersDepartment of Biology, MIT, Cambridge, MA United States.ORCID 0000-0002-9629-348X
Vama RaoSanford Stem Cell Institute and Stem Cell Program, University of California San Diego, La Jolla, CA 92037, United States.
Rushil SureshDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, United States.
Stefan AignerDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, United States.
Michael F HammerBIO5 Institute, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0003-0172-429X
Christopher J YuskaitisDepartment of Neurology, FM Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, USA.ORCID 0000-0002-5643-9798
Megan WongGenetics, Molecular and Cell Biology Program, Tufts University School of Medicine, Boston, MA, United States.
Nicole TeaneyDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, United States.ORCID 0009-0007-9069-4606
Crystal ZhangGenetics, Molecular and Cell Biology Program, Tufts University School of Medicine, Boston, MA, United States.
Mike ThompsonCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.
Ben LehnerCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.
C Frank BennettIonis Pharmaceuticals, Carlsbad, California.ORCID 0000-0001-9887-6251
Juan ValcárcelCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.ORCID 0000-0001-5398-3571
Gene W YeoDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, United States.ORCID 0000-0002-0799-6037
Christopher B BurgeDepartment of Biology, MIT, Cambridge, MA United States.ORCID 0000-0001-9047-5648
Chris G DullaDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, United States.ORCID 0000-0002-6560-6535
Madeleine J OudinTufts University, Department of Biomedical Engineering, Medford, MA, USA.ORCID 0000-0001-6988-4260

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Defining and Exploiting the Neuronal Identity of CancersDP2CA271387 · NCI · TUFTS UNIVERSITY MEDFORD · PI OUDIN, MADELEINE JULIE · 2021 to 2024
$2.3M
Targeting Alternative Splicing of Sodium Channels to Treat Pediatric Developmental Epileptic EncephalopathiesR01NS139468 · NINDS · TUFTS UNIVERSITY MEDFORD · PI CHRISTOPHER B BURGE, Chris G Dulla · 2024 to 2026
$1.8M
NCI NIH HHS DP2 CA271387NICHD NIH HHS P50 HD105351NINDS NIH HHS R01 NS139468
6 · The paper itself

Abstract

Variants in ion channel genes are common causes of pediatric epilepsy, often leading to intractable seizures, developmental delay and other comorbidities, which increases risk of death. Pathogenic variants in the

Identifiers

PMID41278710
PMCPMC12633343

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.