Evidence map›Paper›PMID 41278774›Full record

ArticlebioRxiv : the preprint server for biology2025

The mycomembrane proteins PorH and ProtX are inserted at polar growth zones and linked to the cell wall.

Elizabeth M Hart, Dieuwertje A de Bruin, Victoria M Marando, Marina Arnau Alemany, Eric D Snow, Bailey J Schultz, Erkin Kuru, Suzanne Walker, Andrea Vettiger, Thomas G Bernhardt

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Elizabeth M HartDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0444-6547
Dieuwertje A de BruinDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Victoria M MarandoDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3557-5838
Marina Arnau AlemanyDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Eric D SnowDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-7464-8323
Bailey J SchultzDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4648-0172
Erkin KuruDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2356-0858
Suzanne WalkerDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Andrea VettigerDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-1245-0987
Thomas G BernhardtDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.

Funding

Project 3: Defining and defeating the mechanisms of outer membrane biogenesis in Gram-negative bacteriaU19AI158028 · NIAID · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2022 to 2025
$10.1M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Discovery and characterization of new bacterial cell wall targets and inhibitors to treat resistant infectionsR01AI148752 · NIAID · HARVARD MEDICAL SCHOOL · PI Daniel Kahne, Suzanne Walker · 2020 to 2026
$5.5M
Investigating the mycomembrane protein assembly pathwayK99AI190054 · NIAID · HARVARD MEDICAL SCHOOL · PI Elizabeth Mary Hart · 2025 to 2026
$227k
NIAID NIH HHS K99 AI190054NIAID NIH HHS R01 AI148752NIAID NIH HHS U19 AI158028NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

The Mycobacteriales order of bacteria includes important pathogens such as

Identifiers

PMID41278774
PMCPMC12632848

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.