Evidence map›Paper›PMID 41278785›Full record

ArticlebioRxiv : the preprint server for biology2025

Exercise intensity modulates the human plasma secretome and interorgan communication.

Luke Olsen, Javier Botella, Douglas Barrows, Ethan Romero, Kaitlyn Baird, Mutsumi Katayama, Ece Kilic, Christopher Peralta, Henry Sanford, Laurie Farrell and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Luke OlsenLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA.
Javier BotellaInstitute for Health and Sport, Victoria University, Melbourne, Australia.ORCID 0000-0001-9722-8519
Douglas BarrowsBioinformatics Resource Center, The Rockefeller University, New York, NY 10065, USA.
Ethan RomeroWeill Cornell Medical College, New York, NY 10065, USA.
Kaitlyn BairdDepartment of Rehabilitation and Performance, Hospital for Special Surgery, New York, NY 10021, USA.
Mutsumi KatayamaDepartment of Molecular Medicine and Surgery, and Department of Physiology and Pharmacology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Ece KilicProteomics Resource Center, The Rockefeller University, New York, NY 10065, USA.
Christopher PeraltaProteomics Resource Center, The Rockefeller University, New York, NY 10065, USA.
Henry SanfordLaboratory of Chemical Immunology and Proteomics, The Rockefeller University, New York, NY 10065, USA.
Laurie FarrellDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Christopher L AxelrodIntegrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.ORCID 0000-0002-1444-8557
Kaja PlucińskaLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA.
Jeanne WalkerThe Rockefeller University Hospital, New York, NY 10065, USA.
Lu YanDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Katie FredricksonDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Olivier PourquieDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Jeremy M RobbinsDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Ekaterina V VinogradovaLaboratory of Chemical Immunology and Proteomics, The Rockefeller University, New York, NY 10065, USA.
John P KirwanIntegrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Juleen R ZierathDepartment of Molecular Medicine and Surgery, and Department of Physiology and Pharmacology, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0001-6891-7497
Anna KrookDepartment of Molecular Medicine and Surgery, and Department of Physiology and Pharmacology, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0002-0891-0258
Robert E GersztenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
David J BishopInstitute for Health and Sport, Victoria University, Melbourne, Australia.ORCID 0000-0002-6956-9188
Paul CohenLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA.

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
An Encyclopedia of the Adipose Tissue Secretome to Identify Mediators of Health and DiseaseRC2DK129961 · NIDDK · ROCKEFELLER UNIVERSITY · PI CHAIT, BRIAN T, COHEN, PAUL · 2021 to 2025
$9.2M
Proteomics of Cardiometabolic and Renal Traits in African AmericansR01HL133870 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROBERT E GERSZTEN · 2017 to 2026
$6.7M
Integrative analysis of genomics and proteomics to identify candidate molecular transducers of cardiorespiratory fitnessR03OD038387 · OD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROBBINS, JEREMY · 2024 to 2024
$346k
NCATS NIH HHS UL1 TR004419NHLBI NIH HHS R01 HL133870NIDDK NIH HHS RC2 DK129961NIGMS NIH HHS U54 GM104940NIH HHS R03 OD038387
6 · The paper itself

Abstract

Exercise is recognized as first-line therapy for many cardiometabolic diseases, including obesity, type 2 diabetes, and hypertension. Despite the abundant health-promoting effects of exercise, in-depth characterization of circulatory factors that mediate these benefits in humans remains incomplete. Moreover, how different modes and intensities of exercise uniquely regulate these processes is unclear. Here, we address these questions by conducting a multi-cohort human exercise intervention, incorporating sprint-interval exercise (SIE) and moderate-intensity exercise (MIE) to analyze intensity-dependent regulation of interorgan crosstalk. We find that exercise intensity distinctly influences the plasma proteome and metabolome in both untrained and trained participants. SIE led to immediate and robust changes to the plasma proteome, whereas MIE resulted in delayed secretory kinetics. By leveraging large, multi-organ gene and protein expression datasets, in combination with

Indexed as

ExerciseMetabolismPhysiology

Identifiers

PMID41278785
PMCPMC12633464

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.