Evidence map›Paper›PMID 41278839›Full record

ArticlebioRxiv : the preprint server for biology2025

REST elevation-dependent chromatin remodeling and alternative Grk6 transcript synthesis hyperactivates Cxcr4-Sdf1 signaling in cerebellar granule cell progenitors.

Keri Callegari, Jyothishmathi Swaminathan, Lei Guo, Ashutosh Singh, Yanwen Yang, Xue Xiao, Tara H W Dobson, Amanda R Haltom, Javiera Bravo-Alegria, Ajay Sharma and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Keri CallegariDepartment of Pediatrics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX.ORCID 0000-0003-1433-6659
Jyothishmathi SwaminathanDepartment of Pediatrics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX.ORCID 0000-0001-6648-5467
Lei GuoQuantitative Biomedical Research Center, Department of Health Data Science & Biostatistics, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX.
Ashutosh SinghDepartment of Pediatrics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX.
Yanwen YangDepartment of Pediatrics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX.
Xue XiaoQuantitative Biomedical Research Center, Department of Health Data Science & Biostatistics, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX.
Tara H W DobsonDepartment of Pediatrics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX.
Amanda R HaltomDepartment of Pediatrics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX.
Javiera Bravo-AlegriaDepartment of Pediatrics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX.
Ajay SharmaDepartment of Pediatrics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX.
Xin HuDepartment of Genomic Medicine, The University of Texas, M.D. Anderson Cancer Center, Houston, TX.
Lin XuQuantitative Biomedical Research Center, Department of Health Data Science & Biostatistics, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX.
Vidya GopalakrishnanDepartment of Pediatrics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX.

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7M
Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
Center for Clinical and Translational Sciences (CCTS)TL1TR000369 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$1.9M
Study of a Novel Deubiquitylase in MedulloblastomaR01NS079715 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GOPALAKRISHNAN, VIDYA · 2012 to 2015
$1.4M
Identifying neuroblastoma drivers and bringing them to the clinicR21CA259771 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SKAPEK, STEPHEN X, XU, LIN · 2021 to 2021
$437k
Development of Novel Mouse Models to Study REST Function in MedulloblastomaR03NS077021 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GOPALAKRISHNAN, VIDYA · 2011 to 2012
$158k
NCATS NIH HHS TL1 TR000369NCATS NIH HHS UL1 TR000371NCI NIH HHS P30 CA142543NCI NIH HHS R21 CA259771NINDS NIH HHS R01 NS079715NINDS NIH HHS R03 NS077021
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

alternative transcriptsATACseqcell migrationCxcr4-SDF1 signalingEzh2Grk6RESTRNA-seq

Identifiers

PMID41278839
PMCPMC12632871

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.