Evidence map›Paper›PMID 41278932›Full record

ArticlebioRxiv : the preprint server for biology2025

Spatial transcriptomic profiling identifies lacrimal gland epithelial cell-driven mechanisms underlying autoimmunity in Sjögren's disease.

Shivali Gupta, Athanasios Ploumakis, Nikolaos Kalavros, Sharmila Masli

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Shivali GuptaDepartment of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID 0000-0002-9598-7965
Athanasios PloumakisThe Spatial Technologies Unit, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Nikolaos KalavrosThe Spatial Technologies Unit, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.ORCID 0000-0001-5503-9808
Sharmila MasliDepartment of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID 0000-0001-8612-0617

Funding

Mechanisms underlying mustard gas-induced conjunctival injury and use of lipid mediators as medical countermeasuresR56EY035213 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI DARTT, DARLENE A, MASLI, SHARMILA · 2023 to 2023
$583k
NEI NIH HHS R56 EY035213
6 · The paper itself

Abstract

Sjögren's disease (SjD) is a second most prevalent rheumatic disease involving autoimmune pathology of tear-producing lacrimal glands that leads to a common clinical manifestation of chronic ocular surface disease. Despite advances in understanding of SjD, lacrimal gland pathology remains incompletely understood limiting diagnosis and treatment. Here we analyze spatial transcriptomic profile of lacrimal glands from wild-type (C57Bl/6) mice and Thrombospondin (TSP)-1

Indexed as

AutoimmunityBiological Sciences (Major)Lacrimal glandMedical Sciences (Minor)OphthalmologySjögren’s diseaseSpatial transcriptomics

Identifiers

PMID41278932
PMCPMC12637439

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.