Evidence map›Paper›PMID 41278950›Full record

ArticlebioRxiv : the preprint server for biology2025

Comparative gene editing reduces dopamine receptor levels across rodent species.

Sonia C Karkare, Dario Aspesi, Keith M Garner, Evelien H S Schut, H Elliott Albers, Frank J Meye, Malavika Murugan, Arjen J Boender

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sonia C KarkareThese authors contributed equally to this work.
Dario AspesiThese authors contributed equally to this work.
Keith M GarnerDepartment of Translational Neuroscience, Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Evelien H S SchutDepartment of Translational Neuroscience, Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
H Elliott AlbersNeuroscience Institute, Georgia State University, Atlanta, GA, USA. Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA.
Frank J MeyeDepartment of Translational Neuroscience, Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Malavika MuruganNeuroscience Institute, Georgia State University, Atlanta, GA, USA. Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA.
Arjen J BoenderCenter for Translational Social Neuroscience, Emory University, Atlanta, United States.ORCID 0000-0002-6018-3588

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Sex-dependent regulation of social reward by oxytocin in the mesolimbic reward circuitryR01MH122622 · NIMH · GEORGIA STATE UNIVERSITY · PI ALBERS, H. ELLIOTT, HUHMAN, KIM L · 2021 to 2025
$2.7M
Prefrontal circuits in processing social versus non-social rewardsR01MH130755 · NIMH · EMORY UNIVERSITY · PI Malavika Murugan · 2023 to 2026
$1.5M
NIH HHS P51 OD011132NIMH NIH HHS R01 MH122622NIMH NIH HHS R01 MH130755
6 · The paper itself

Abstract

Translational challenges in neuroscience originate from species-specific differences that limit the generalizability of experimental findings. Comparative approaches can help distinguish conserved from species-specific mechanisms, but their application has been limited by the lack of molecular tools beyond traditional model organisms, complicating direct comparisons of conserved and divergent mechanisms of neural function. This gap is particularly evident for the dopaminergic system, a key regulator of motivated behaviors across species and the principal pharmacological target for current psychotherapies. Building on our recent development of comparative gene editing, we here present an adeno-associated virus-mediated CRISPR/Cas9 strategy to reduce

Identifiers

PMID41278950
PMCPMC12633220

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.