Evidence map›Paper›PMID 41278972›Full record

ArticlebioRxiv : the preprint server for biology2025

Condensate-Driven Triglyceride Depletion Links α-Synuclein to Mitochondrial Dysfunction.

Tao Zhang, María Eugenia Goya, Alejandro Herron-Bedoya, Jorien C van der Weerd, Dikaia Tsagkari, Suzanne Couzijn, Lale Güngördü, Renée I Seinstra, M Rebecca Heiner Fokkema, Ming Chang and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Tao ZhangEuropean Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands.ORCID 0000-0001-8653-5089
María Eugenia GoyaEuropean Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands.
Alejandro Herron-BedoyaEuropean Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands.
Jorien C van der WeerdDepartment of Laboratory Medicine, University of Groningen, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Dikaia TsagkariInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 70013, Crete, Greece.
Suzanne CouzijnEuropean Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands.
Lale GüngördüEuropean Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands.
Renée I SeinstraEuropean Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands.
M Rebecca Heiner FokkemaDepartment of Laboratory Medicine, University of Groningen, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Ming ChangState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Nektarios TavernarakisInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 70013, Crete, Greece.ORCID 0000-0002-5253-1466
Folkert KuipersEuropean Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands.
Ellen A A NollenEuropean Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands.ORCID 0000-0003-3740-6373

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Inclusions of α-Synuclein (αSyn) characterize multiple age-related neurodegenerative diseases, including Parkinson's disease (PD) and Multiple System Atrophy (MSA). While interactions between αSyn and lipids are known to contribute to αSyn pathobiology, the precise cellular mechanisms that link lipids to αSyn toxicity have yet to be elucidated. Through lipidomic profiling of

Indexed as

C. eleganscondensatesDementia with Lewy Bodies (DLB)lipid dropletsmitochondrial respirationMultiple System Atrophy (MSA)Parkinson’s Diseasesynucleinopathiestriacylglycerolsα-synuclein

Identifiers

PMID41278972
PMCPMC12633352

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.