Evidence map›Paper›PMID 41279031›Full record

ArticlebioRxiv : the preprint server for biology2025

The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism.

Ahmed Rattani, Cora Anderson, William V Trim, Esteban Garita, Shinya Imada, Saleh Khawaled, Heaji Shin, Jiuchun Zhang, Ömer H Yilmaz, Marc Kirschner

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ahmed RattaniDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-1058-7314
Cora AndersonDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-9397-9534
William V TrimDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-5642-0608
Esteban GaritaDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0334-658X
Shinya ImadaDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA 02139, USA.
Saleh KhawaledDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA 02139, USA.ORCID 0000-0002-2315-3697
Heaji ShinDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA 02139, USA.ORCID 0000-0001-5208-5999
Jiuchun ZhangDepartment of Cell Biology, Harvard Medical School, Boston, MA, 02115.ORCID 0009-0006-5513-5844
Ömer H YilmazDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA 02139, USA.
Marc KirschnerDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jacqueline A. Lees · 1985 to 2026
$93.9M
Tissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI SHIVDASANI, RAMESH A · 2007 to 2023
$33.2M
The dynamics and underlying mechanisms controlling cell size and canonical Wnt signalingR35GM145248 · NIGMS · HARVARD MEDICAL SCHOOL · PI MARC Wallace KIRSCHNER · 2022 to 2026
$3.9M
Effects of inflammaging on intestinal epithelial cells and aspirin chemoprevention.R01CA257523 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T, STAPPENBECK, THADDEUS S · 2021 to 2025
$3.7M
Mechanisms of HIV-associated epithelialintestinal stem cell (ISC) dysfunctionR01DK126545 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KLOVERPRIS, HENRIK, KWON, DOUGLAS · 2020 to 2024
$3.6M
Immunometabolic regulation of CD8+ T cell mediated intestinal epithelial cell death in people with HIV (PWH)R01DK133919 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Douglas Kwon, Omer Yilmaz · 2022 to 2026
$3.5M
The lysosomal fasting response in intestinal stem cells and cancerR01DK140310 · NIDDK · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Omer Yilmaz · 2024 to 2026
$2.4M
Impact of fasting on intestinal stem cells and cancerR01CA245314 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Omer Yilmaz · 2020 to 2026
$2.3M
PROSPECT - Stem cell modelsOT2CA297570 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Omer Yilmaz · 2024 to 2026
$1.4M
NCI NIH HHS OT2 CA297570NCI NIH HHS P30 CA014051NCI NIH HHS P50 CA127003NCI NIH HHS R01 CA245314NCI NIH HHS R01 CA257523NIDDK NIH HHS R01 DK126545NIDDK NIH HHS R01 DK133919NIDDK NIH HHS R01 DK140310NIGMS NIH HHS R35 GM145248
6 · The paper itself

Abstract

APC, the core scaffold of the Wnt destruction complex, targets the transcriptional co-activator β-catenin for proteolysis. There is no convincing evidence that APC directs degradation of other substrates. Using a reconstituted cytosolic extract-based system and complementary in vivo and cellular assays, we show that SREBP2, the master regulator of cholesterol biosynthesis, is a direct APC-AXIN1 substrate. APC-dependent SREBP2 degradation is conserved in

Identifiers

PMID41279031
PMCPMC12632877

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.