Evidence map›Paper›PMID 41279033›Full record

ArticlebioRxiv : the preprint server for biology2025

Immune transcriptomic differences in paediatric patients with SARS-CoV-2 compared to other lower respiratory tract infections.

Negusse Tadesse Kitaba, Lesley Workman, Cheryl Cohen, Diana Baralle, Ellen Kong, Maresa Botha, Marina Johnson, David Goldblatt, Mark P Nicol, John W Holloway and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Negusse Tadesse KitabaHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0001-7518-9096
Lesley WorkmanDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa.
Cheryl CohenCenter for Respiratory disease and Meningitis, National Institute for Communicable Diseases, a division of the National Health Laboratory Service, 1 Modderfontein Road Sandringham, South Africa.ORCID 0000-0003-0376-2302
Diana BaralleHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0003-3217-4833
Ellen KongNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0009-0005-0621-0660
Maresa BothaDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-0200-5273
Marina JohnsonGreat Ormond Street Institute of Child Health University College London, UK.
David GoldblattGreat Ormond Street Institute of Child Health University College London, UK.ORCID 0000-0002-0769-5242
Mark P NicolThe University of Western Australia: Perth, Australia.ORCID 0000-0002-1366-4805
John W HollowayHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0001-9998-0464
Heather J ZarDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-9046-759X

Funding

The nasopharyngeal microbiota of African children and lower respiratory tract infectionU54HG009824 · NHGRI · UNIVERSITY OF CAPE TOWN · PI NICOL, MARK PATRICK, ZAR, HEATHER JOY · 2017 to 2021
$2.9M
The nasopharyngeal microbiome and respiratory disease in African childrenU01AI110466 · NIAID · UNIVERSITY OF CAPE TOWN · PI NICOL, MARK PATRICK, ZAR, HEATHER JOY · 2013 to 2016
$1.4M
NHGRI NIH HHS U54 HG009824NIAID NIH HHS U01 AI110466Wellcome Trust
6 · The paper itself

Abstract

The clinical severity of SARS-CoV-2 infection in children varies, with asymptomatic or mild illness predominating and a minority developing severe disease. Understanding the immunological responses that underlie severity of disease may guide future development of preventive or therapeutic interventions. This study compared whole blood transcriptomes of healthy children (N=127), children with mild/asymptomatic SARS-CoV-2 infection (N=71) and children hospitalised with severe SARS-COV-2 (N=41), lower respiratory tract illness (LRTI) or LRTI due to Respiratory Syncytial Virus (RSV-LRTI) (N=47) or Pulmonary Tuberculosis (PTB) (N=47). We identified >5000 differentially expressed genes including:

Indexed as

ChildCovid-19PTBRespiratory infectionRSV-LRTIWGCNA

Identifiers

PMID41279033
PMCPMC12637703

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.